Diabetes and cognitive decline in elderly African Americans: A 15‐year follow‐up study
| Autor: | Kathleen S. Hall, Hugh C. Hendrie, Kathleen A. Lane, Sujuan Gao, Frederick W. Unverzagt, Alette M. Wessels |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Gerontology Heart disease Epidemiology Neuropsychological Tests Article Cellular and Molecular Neuroscience Developmental Neuroscience Residence Characteristics Risk Factors Diabetes mellitus Diabetes Mellitus medicine Humans Dementia Longitudinal Studies Cognitive decline Stroke Depression (differential diagnoses) Aged Aged 80 and over Psychiatric Status Rating Scales Chi-Square Distribution Health Policy Repeated measures design Cognition medicine.disease Black or African American Psychiatry and Mental health Female Neurology (clinical) Geriatrics and Gerontology Cognition Disorders Psychology |
| Zdroj: | Alzheimer's & Dementia. 7:418-424 |
| ISSN: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2010.07.003 |
| Popis: | Background Diabetes mellitus is associated with an increased risk for cognitive impairment and vascular factors seem to play a role in this relationship. In a sample involving elderly African Americans, we tested the hypothesis that diabetes accelerates cognitive decline and explored possible mediating mechanisms within a follow-up period of 15 years. Methods A total of 1702 subjects, of whom 441 had diabetes, were given the community screening interview for dementia to measure cognitive functioning at six different time points spread over a 15-year follow-up period. Mixed effects models with repeated measures were used to examine the association of diabetes and vascular risk factors with cognitive scores over time. Results African American subjects with diabetes reported having a significant accelerated cognitive decline as compared with those without diabetes ( P = .046), when controlling for basic demographics and baseline comorbid conditions (heart disease, hypertension, stroke, and depression). Adjusting for incident heart disease, and especially stroke, weakened this association ( P = .098), thereby indicating a mediating effect of stroke on the association between diabetes and cognitive decline. However, when incident stroke was incorporated into the model, the effect for participants with diabetes increased greatly ( P = .007). Conclusions Diabetes, mediated by cerebrovascular pathology, accelerates cognitive decline within a follow-up period of 15 years in a sample comprising African Americans. |
| Databáze: | OpenAIRE |
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