The role of enteric glia in gut inflammation
| Autor: | Georg B T von Boyen, M. Steinkamp |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Gut inflammation
Chagas disease Inflammation Cell Biology Disease Biology Inflammatory Bowel Diseases medicine.disease Models Biological Inflammatory bowel disease Enteric Nervous System Cellular and Molecular Neuroscience Immunology medicine Animals Humans Chagas Disease Secretion Enteric nervous system medicine.symptom Neuroglia Gut homeostasis |
| Zdroj: | Neuron Glia Biology. 6:231-236 |
| ISSN: | 1741-0533 1740-925X |
| Popis: | A neuro-glia interaction is part of gut inflammation and essential for the integrity of the bowel. A loss of enteric glia cells (EGCs) led to a fatal haemorrhagic jejuno-ileitis and death in a few days. Although a diminished EGC network is postulated in inflammatory bowel disease and enteric glia pathology is described in Chagas' disease the role of EGCs in the onset of these disease complexes is not definitely clear. Several lines of evidence implicate that the secretion of different factors by enteric glia may be the key for modulating gut homeostasis. As mucosal integrity might be important for remission in Crohn's disease and inflammation of the enteric nervous system is part of the pathology in Chagas' disease, the role of EGCs during gut inflammation could be part of the key to understand these diseases. |
| Databáze: | OpenAIRE |
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