Neonatal DHT but not E2 speeds induction of sexual receptivity in the musk shrew
| Autor: | Andrea Jackson, Tiffany A. Ewton, Ruth B. Siboni, Louise M. Freeman |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class media_common.quotation_subject Receptivity Experimental and Cognitive Psychology Stimulus (physiology) Biology Article Courtship Behavioral Neuroscience Sexual Behavior Animal Internal medicine medicine Animals media_common Motivation Sexual differentiation Estradiol Shrews Age Factors Dihydrotestosterone Estrogens Androgen Altricial Endocrinology Animals Newborn Estrogen Androgens Female medicine.drug |
| Zdroj: | Physiologybehavior. 100(3) |
| ISSN: | 1873-507X |
| Popis: | Neural aromatization of testosterone (T) to estrogen during development is thought to be important for sexual differentiation of many altricial mammals. We evaluated the effects of neonatal injections of the non-aromatizable androgen dihydrotestosterone propionate (DHTP) and estradiol (E2) on the copulatory behavior of the female musk shrew, an altricial insectivore. Following adult ovariectomy and replacement T, animals were paired with a stimulus female for two 60-minute copulatory behavior tests. The latency to induce sexual receptivity (in the form of tail-wagging by the female), mount latency and total number of mounts were recorded in experimental females and in a group of untreated control males. While neither hormone treatment significantly affected mounting behavior, DHTP-treated animals induced receptivity faster and with latencies not significantly different from intact males, suggesting that early non-aromatizable androgens can have masculinizing actions by either increasing sexual motivation or making the treated animal more attractive to the stimulus female. Reliance on androgenic rather than estrogenic metabolites for the differentiation of courtship behaviors conforms to the pattern seen more typically in primates than rodents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect