Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis
| Autor: | Selma Şengiz Erhan, Cem Zeki Esenyel, Zuleyha Erisgin, Kürşad Aytekin, Selçuk Takır |
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| Přispěvatelé: | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı, Aytekin, Kürşad |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Intra-Articular Physiology Hydrogen sulfide Sodium hydrosulfide Osteoarthritis 030204 cardiovascular system & hematology Methylprednisolone Injections Intra-Articular 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Intra articular Physiology (medical) Internal medicine Gonarthrosis medicine Animals Synovial fluid Knee Hydrogen Sulfide Rats Wistar Meniscectomy Pharmacology Gasotransmitters General Medicine Osteoarthritis Knee medicine.disease Rats Endocrinology chemistry Disease Progression 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 97:47-54 |
| ISSN: | 1205-7541 0008-4212 |
| Popis: | WOS: 000455018200005 PubMed: 30521368 Hydrogen sulfide (H2S) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 mu L), a H2S donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Then, intra-articular injections of NaSH or methylprednisolone (1 mg/kg, 30 mu L) were administered to rats. Half of each group was sacrificed at the end of the first day and the other half was sacrificed at the end of 4 weeks to evaluate early and later effects of injections on gonarthrosis. The injury induced by anterior cruciate ligament resection and medial meniscectomy in rats caused the development of gonarthrosis. As the duration lengthened after gonarthrosis induction, the progression of the disease continued. According to the modified Mankin Scoring System, intra-articular injection of NaSH histopathologically slowed the progression of gonarthrosis, whereas methylprednisolone was ineffective. In addition, NaSH decreased apoptosis in rat knees with gonarthrosis. Each treatment did not cause injury to healthy knees. Our results lead to the consideration that intra-articular NaSH administration may be effective in the progression of gonarthrosis. Giresun University Scientific Research Center [SAG-BAP-A-160317-75] This study was funded by a grant from Giresun University Scientific Research Center (SAG-BAP-A-160317-75). Author contributions: the study was designed by K. Aytekin and S. Takir; all experimental procedures with surgical processes were done by K. Aytekin, C.Z. Esenyel, and S. Takir; histopathological experiments were done by S.S. Erhan and Z. Erisgin; all authors also contributed to the writing of the manuscript. |
| Databáze: | OpenAIRE |
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