Effects of Some New Antioxidants on Apoptosis and ROS Production in AFB1 Treated Chickens
| Autor: | Vincenzo Romano, Emanuela Andretta, Giuseppina Avantaggiato, Achille Schiavone, Salvatore Florio, Roberto Ciarcia, Sara Damiano, Chiara Lauritano, Watanya Jarriyawattanachaikul, Consiglia Longobardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
feed additive
Aflatoxin kidney Antioxidant 040301 veterinary sciences medicine.medical_treatment Feed additive medicine.disease_cause 0403 veterinary science Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound medicine oxidative stress Food science Mycotoxicosis 030304 developmental biology 2. Zero hunger 0303 health sciences NADPH oxidase biology NOX4 ROS 04 agricultural and veterinary sciences chemistry aflatoxin B1 biology.protein chickens Oxidative stress |
| Zdroj: | The 1st International e-Conference on Antioxidants in Health and Disease, pp. 1–6, On-line, 1-15/12/2020 info:cnr-pdr/source/autori:Consiglia Longobardi 1, Emanuela Andretta 2, Vincenzo Romano 2, Chiara Lauritano 3, Giuseppina Avantaggiato 4, Achille Schiavone 5, Watanya Jarriyawattanachaikul 5, Salvatore Florio 2, Roberto Ciarcia 2 and Sara Damiano 2/congresso_nome:The 1st International e-Conference on Antioxidants in Health and Disease/congresso_luogo:On-line/congresso_data:1-15%2F12%2F2020/anno:2021/pagina_da:1/pagina_a:6/intervallo_pagine:1–6 The 1st International E-Conference on Antioxidants in Health and Disease, pp. 1–7, 01-15/12/2020 info:cnr-pdr/source/autori:Consiglia Longobardi 1, Emanuela Andretta 2, Vincenzo Romano 2, Chiara Lauritano 3, Giuseppina Avantaggiato 4, Achille Schiavone 5, Watanya Jarriyawattanachaikul 5, Salvatore Florio 6, Roberto Ciarcia 6, Sara Damiano 6/congresso_nome:The 1st International E-Conference on Antioxidants in Health and Disease/congresso_luogo:/congresso_data:01-15%2F12%2F2020/anno:2020/pagina_da:1/pagina_a:7/intervallo_pagine:1–7 |
| Popis: | Aflatoxin B1 (AFB1), the mainly Aspergillus fungi derived mycotoxin, is well known for its carcinogenic effects on liver, and frequently occurs in food supplies, leading to fatal consequences in both farm animals and humans. Poultry, one of the most important segments of agro-industry, has been demonstrated to be extremely sensitive to AFB1 intake, which results in chickens’ low performance, decreased quality of both eggs and meat and a negative economic feedback. Oxidative stress caused by AFB1 plays a crucial role in chickens’ kidney damage by generating lipid peroxidation accompanied by a concomitant increase in the antioxidant enzymes involved in ROS metabolism (NADPH oxidase isoform 4 (NOX4) and its regulatory subunit p47-phox). The aim of the present work was to investigate the benefits of dietary supplementation, in chickens affected by AFB1 mycotoxicosis, using a new Feed additive (FA) containing a mixture of a tri-octahedral Na-smectite with a ligno-cellulose-based material an antioxidant adjuvant. Exposure of AFB1-treated chickens to the feed additive induced a significant down-regulation of both NOX4 and p47-phox genes expression levels. This trend was confirmed by their protein expression, demonstrating the great potential of the FA to counteract oxidative stress. To conclude, these results could open new perspectives in the methods of feeding chickens, using eco-friendly dietary supplements able to reduce AFB1-induced mycotoxicosis and to ameliorate poultry performances. |
| Databáze: | OpenAIRE |
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