Insulin resistance, LDL particle size, and LDL susceptibility to oxidation in pediatric kidney and liver recipients
| Autor: | Matti K. Salo, Tiina Solakivi, Hannu Jokela, Marja Ala-Houhala, Marjatta Antikainen, Suvi M. Virtanen, Arja Siirtola, Terho Lehtimäki, Christer Holmberg, Anna-Maija Koivisto |
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| Rok vydání: | 2005 |
| Předmět: |
Blood Glucose
Male Nephrology kidney insulin medicine.medical_specialty Adolescent Apolipoprotein B medicine.medical_treatment In Vitro Techniques Liver transplantation liver Combined hyperlipidemia Insulin resistance lipid Internal medicine medicine Humans triglyceride Particle Size glucose Hypertriglyceridemia child biology medicine.diagnostic_test business.industry medicine.disease Kidney Transplantation Lipids Liver Transplantation Lipoproteins LDL Transplantation Cross-Sectional Studies Endocrinology Case-Control Studies Child Preschool LDL particle size biology.protein Female lipids (amino acids peptides and proteins) Insulin Resistance LDL oxidation business Lipid profile Oxidation-Reduction transplantation Lipoprotein |
| Zdroj: | Kidney International. 67:2046-2055 |
| ISSN: | 0085-2538 |
| DOI: | 10.1111/j.1523-1755.2005.00307.x |
| Popis: | Insulin resistance, LDL particle size, and LDL susceptibility to oxidation in pediatric kidney and liver recipients.BackgroundDyslipidemia is common after solid organ transplantation. We have described hypertriglyceridemia in about 50% of our pediatric kidney, and in about 30% of our liver recipients. The aim of the present study was to find out whether this post-transplantation hypertriglyceridemia after pediatric solid organ transplantation is associated with insulin resistance and the occurrence of small, dense low-density lipoprotein (LDL).MethodsFifty kidney and 25 liver recipients (aged 4 to 18 years) on triple immunosuppression, and 181 control children participated in the study for an average of 5.3 and 6.4 years after kidney and liver transplantation (range 1 to 11 years), respectively. Homeostasis model assessments for insulin resistance (HOMA) were calculated and fasting lipoprotein lipid profile, apolipoprotein A-I and B concentrations, LDL particle diameter, and indices of LDL susceptibility to copper-induced oxidation determined.ResultsKidney patients had significantly higher serum total, high-density, and low-density lipoprotein cholesterol, triglyceride, apolipoprotein A-I and B concentrations than liver patients or control subjects (P < 0.003 for all). HOMA indices higher than the 95th percentile of Canadian normal children were seen in 50.0% of kidney (of liver 41.2%) recipients younger than 11 years, and in 27.3% of older recipients (of liver 37.5%). Smaller sized LDL or LDL of increased oxidizability was not more frequent in patients than in control children.ConclusionPediatric kidney recipients had significantly higher lipid and insulin concentrations than healthy control children. Combined hyperlipidemia and features of the dysmetabolic syndrome were common in children after kidney and liver transplantation. However, no small, dense LDL, or LDL prone to oxidation was seen in either group. |
| Databáze: | OpenAIRE |
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