Intracellular Trafficking Considerations in the Development of Natural Ligand-Drug Molecular Conjugates for Cancer
| Autor: | Dennis J. Yoon, Daniel T. Kamei, Christina T. Liu, Parsa M. Nafisi, Devin Quinlan |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
Folate media_common.quotation_subject Biomedical Engineering Biological Transport Active Exotoxins Antineoplastic Agents Ricin Biology Ligands Models Biological Article 03 medical and health sciences Folic Acid 0302 clinical medicine Neoplasms Receptors Transferrin medicine Humans Diphtheria Toxin Doxorubicin Receptor 030304 developmental biology media_common Drug Carriers 0303 health sciences Interleukin-13 Epidermal Growth Factor Ligand Receptors Interleukin-13 Transferrin food and beverages Transforming Growth Factor alpha Transforming growth factor-α 3. Good health ErbB Receptors Biochemistry 030220 oncology & carcinogenesis Interleukin 13 Targeted delivery Signal transduction Drug carrier Intracellular Folic Acid Transporters Signal Transduction medicine.drug |
| Zdroj: | Annals of Biomedical Engineering |
| ISSN: | 1573-9686 0090-6964 |
| Popis: | Overexpressed receptors, characteristic of many cancers, have been targeted by various researchers to achieve a more specific treatment for cancer. A common approach is to use the natural ligand for the overexpressed receptor as a cancer-targeting agent which can deliver a chemically or genetically conjugated toxic molecule. However, it has been found that the therapeutic efficacy of such ligand-drug molecular conjugates can be limited, since they naturally follow the intracellular trafficking pathways of the endogenous ligands. Therefore, a thorough understanding of the intracellular trafficking properties of these ligands can lead to novel design criteria for engineering ligands to be more effective drug carriers. This review presents a few commonly used ligand/receptor systems where intracellular trafficking considerations can potentially improve the therapeutic efficacy of the ligand-drug molecular conjugates. |
| Databáze: | OpenAIRE |
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