Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure
| Autor: | Jørgen Koch, Camila Peres Rubio, Ryou Tanaka, José J. Cerón, Meriç Kocatürk, Zeki Yilmaz, Ahmet Saril |
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| Přispěvatelé: | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı., Sarıl, Ahmet, Kocatürk, Meriç, Yılmaz, Zeki, DQX-5263-2022, GGO-7900-2022 |
| Rok vydání: | 2020 |
| Předmět: |
Veterinary sciences
Serum Male Digoxin Left atrial Total antioxidant capacity Interleukin 6 Interleukin 7 Interleukin 8 Spironolactone Interleukin 2 Gastroenterology Antioxidants 0403 veterinary science 0302 clinical medicine Pathology Protein concentrations ABTS radical scavenging assay lcsh:Veterinary medicine Immunoturbidimetry Correlation analysis General Medicine Gamma interferon inducible protein 10 Trolox equivalent antioxidant capacity Blood Echocardiography Cytokines Antioxidant Cardiomyopathies Torasemide medicine.medical_specialty Tumor necrosis factor Heart failure Article Proinflammatory cytokine 03 medical and health sciences Dog disease Mitral valve Animal experiment Pimobendan Markers General Veterinary Volume Animal Paraoxonase 1 Interleukin 18 Cholinesterase medicine.disease Valvular heart disease Mitral Valve Disease Cavalier King Charles Spaniel Congestive cardiomyopathy Haptoglobin Oxidative stress lcsh:SF600-1100 Biomarkers Mitral-valve disease Veterinary medicine Monocyte chemotactic protein 1 030204 cardiovascular system & hematology medicine.disease_cause Pathogenesis Diltiazem Interleukin 10 Enalapril Furosemide Interleukin 15 Dog Dog diseases C reactive protein Urea nitrogen blood level Dilated cardiomyopathy 04 agricultural and veterinary sciences PON1 Keratinocyte derived chemokine Heart ventricle remodeling Female Thorax radiography medicine.symptom Chemokines Research Article Cardiomyopathy 040301 veterinary sciences Inflammation Asymptomatic Antioxidant assay Dogs Internal medicine medicine Animals Cytokine Gamma interferon Ferritin Systemic inflammation business.industry Heart valve diseases Troponin I Bilirubin Aryldialkylphosphatase 1 Nonhuman Biological marker Granulocyte macrophage colony stimulating factor business Thiazide diuretic agent Controlled study |
| Zdroj: | BMC Veterinary Research, Vol 16, Iss 1, Pp 1-14 (2020) Rubio, C P, Saril, A, Kocaturk, M, Tanaka, R, Koch, J, Ceron, J J & Yilmaz, Z 2020, ' Changes of inflammatory and oxidative stress biomarkers in dogs with different stages of heart failure ', BMC Veterinary Research, vol. 16, no. 1, 433 . https://doi.org/10.1186/s12917-020-02650-7 BMC Veterinary Research |
| DOI: | 10.21203/rs.3.rs-24928/v2 |
| Popis: | Background Heart failure (HF) is associated with changes in inflammatory and oxidative stress biomarkers. This study aimed to evaluate the changes of a panel of inflammatory and oxidative stress biomarkers in dogs with different stages of HF and its relation with the severity of the disease and echocardiographic changes. A total of 29 dogs with HF as a result of myxomatous mitral valve degeneration or dilated cardiomyopathy were included and classified as stage-A (healthy), B (asymptomatic dogs), C (symptomatic dogs) and D (dogs with end-stage HF) according to the ACVIM staging system. In these dogs an ecnhocardiographic examination was performed and cytokines, and inflammatory and oxidative stress markers were evaluated in serum. Results KC-like was significantly increased in dogs of stage-C (P P P P P Conclusion Our results showed that dogs with advanced HF show increases in positive acute-phase proteins and selected inflammatory cytokines such as KC-like, and decreases in antioxidant biomarkers, indicating that inflammation and oxidative stress act as collaborative partners in the pathogenesis of HF. Some of these biomarkers of inflammation and oxidative stress could have the potential to be biomarkers to monitor the severity of the disease and the effect of treatment. |
| Databáze: | OpenAIRE |
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