Synthesis and fungicidal activity of novel imidazo[4, 5-b]pyridine derivatives
| Autor: | Huang Lu, Liu Weidong, Minhua Liu, Li Zhong, Mingming Dang, Yeguo Ren, Zhang Zai, Xingping Liu, Daoxin Wu, Aiping Liu, Li Jianming |
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| Rok vydání: | 2019 |
| Předmět: |
fungicidal activity
synthesis 010405 organic chemistry Chemistry structure-activity relationship imidazo[4 5-b]pyridine Organic Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound QD241-441 Pyridine Structure–activity relationship |
| Zdroj: | Heterocyclic Communications, Vol 25, Iss 1, Pp 8-14 (2019) |
| ISSN: | 2191-0197 |
| DOI: | 10.1515/hc-2019-0003 |
| Popis: | A series of novel imidazo[4,5-b]pyridine derivatives were synthesized and their structures were characterized by NMR spectroscopy, mass spectrometry and elemental analysis. The results of bioassays showed that some compounds exhibit good fungicidal activity against Puccinia polysora In particular, compound 7b showed an EC50 value of 4.00 mg/L, which was comparable with that of tebuconazole. Besides, preliminary structure-activity relationship was discussed. |
| Databáze: | OpenAIRE |
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