Sequence analysis of the lactoferrin gene and variation of g.7605C→T in 10 Chinese indigenous goat breeds
| Autor: | Rongyan Zhou, Hong-Yuan Zhao, Lanhui Li, Jing-Fen Kang, Xianglong Li, Huiqin Zheng |
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| Rok vydání: | 2010 |
| Předmět: |
Untranslated region
China Genotype Sequence analysis Molecular Sequence Data Biology Breeding Biochemistry Gene flow Exon Gene Frequency Genetics Animals Point Mutation Allele Molecular Biology Gene Ecology Evolution Behavior and Systematics Alleles Phylogeny Genetic diversity Sheep Base Sequence Goats Genetic Variation General Medicine Exons Sequence Analysis DNA Introns Lactoferrin Cattle |
| Zdroj: | Biochemical genetics. 49(1-2) |
| ISSN: | 1573-4927 |
| Popis: | Much attention has been focused on the study of lactoferrin at the protein or nucleotide level in mice, humans, and cattle, but little is known about it in goats. The goat LF gene from 5′ UTR to exon 17 was amplified, and the variation of g.7605C→T in 10 Chinese indigenous goat breeds was analyzed. Among the three ruminant species (cattle, sheep, and goats), the intron–exon distribution pattern was similar, and all the exons had the same length, but the length of introns varied greatly due to insertions or deletions. The frequency of allele T at g.7605C→T (50.12%) was a little higher than that of allele C (49.88%), and the genotype distribution differed greatly between goat populations. The g.7605C→T site showed higher genetic diversity in goat populations. The genetic differentiation was 0.0783, and gene flow was 2.9433 among the 10 Chinese indigenous goat populations. |
| Databáze: | OpenAIRE |
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