An Experimental Approach to the Interrelationship Between Hyperthyroidism and Ejaculation Latency Time in Male Rats
| Autor: | Tevfik Demir, Nergis Murat, Omer Demir, Ahmet Cihan, Ahmet Adil Esen, Sedef Gidener, Güven Aslan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Ejaculation Urology Bulbospongiosus muscle Spontaneous recovery para-Chloroamphetamine Electromyography Hyperthyroidism Random Allocation chemistry.chemical_compound Seminal vesicle Reference Values Internal medicine Premature ejaculation medicine Animals Rats Wistar p-Chloroamphetamine Probability Analysis of Variance medicine.diagnostic_test business.industry Bulbospongiosus Seminal Vesicles Rats Disease Models Animal Thyroxine Endocrinology medicine.anatomical_structure chemistry medicine.symptom business Injections Intraperitoneal |
| Zdroj: | Journal of Urology. 181:907-912 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/j.juro.2008.10.061 |
| Popis: | We investigated the effects of experimentally induced hyperthyroidism on seminal vesicle pressure measurements and bulbospongiosus muscle contractile activity in a para-chloroamphetamine (Sigma-Aldrich) induced ejaculation model in rats.Male Wistar rats were used in the study. Daily injection of 25 microg/100 gm body weight L-thyroxine (T4, Sigma-Aldrich) for 14 days was performed in 14 rats to induce hyperthyroidism. Seven L-thyroxine injected rats were in the hyperthyroid group. The remaining 7 rats (recovery group) underwent operation after a 28-day washout period to determine spontaneous recovery from hyperthyroidism. At each operation seminal vesicle catheterization was done to measure intraluminal pressure and bulbospongiosus muscle dissection was performed for electromyography. After intraperitoneal administration of 5 mg/kg para-chloroamphetamine physiological parameters related to the ejaculatory process were measured.The interval between para-chloroamphetamine administration and first ejaculation was significantly decreased in the hyperthyroid rat group compared with that in the control group (mean +/- SD 202.8 +/- 22.3 vs 465.4 +/- 104.6 seconds, p = 0.001). Seminal vesicle phasic contraction frequency was significantly higher than control group values in hyperthyroid rats (for 30 minutes 32.3 +/- 13.9, p = 0.047). The mean AUC of bulbospongiosus muscle electromyography activity was also significantly increased in this group (11.1 +/- 4.1 V per second x 10(-4), p = 0.0001). All parameters in recovery and control group rats were not significantly differed from each other.Hyperthyroidism leads to enhanced seminal vesicle contraction frequency and bulbospongiosus muscle contractile activity in rats. Hyperthyroidism affects the emission and expulsion phases of ejaculation in reversible fashion. |
| Databáze: | OpenAIRE |
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