Contribution of NMR spectroscopy to the differential diagnosis of a recurrent cranial mass 7 years after irradiation for a pediatric ependymoma
| Autor: | Pierre Philippet, Isabelle Rutten, Marc Lemort, Shih-Li Chao, Daniel Raket, Nadine Francotte |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Ependymoma medicine.medical_specialty Pathology Magnetic Resonance Spectroscopy medicine.medical_treatment Fourth ventricle Diagnosis Differential Meningioma Lesion medicine Humans Pediatric ependymoma Longitudinal Studies Child Retrospective Studies Fourth Ventricle Radiotherapy Brain Neoplasms business.industry General Medicine medicine.disease Radiation therapy Pediatrics Perinatology and Child Health Neurology (clinical) Neurosurgery Radiology medicine.symptom Differential diagnosis business |
| Zdroj: | Child's Nervous System. 22:1475-1478 |
| ISSN: | 1433-0350 0256-7040 |
| DOI: | 10.1007/s00381-006-0111-x |
| Popis: | We describe the case of a 5-year-old-boy who underwent surgery and focal radiotherapy for an anaplastic ependymoma of the fourth ventricle. One year later, a spinal metastasis was treated the same way. Six years later, a 16-mm lesion was found on a control MRI in the posterior fossa. To help the differential diagnosis between a relapse, a radio-induced modification, and a new tumor, magnetic resonance spectroscopy was performed. The main findings were a peak at the expected resonance frequency of reduced glutathione, a prominent peak of glutamate/glutamine compounds, a low N-acetylaspartate, and the absence of elevated choline. These findings were suggestive of a meningioma, although the latency between irradiation and development of the lesion was quite short. The diagnosis was confirmed by the pathological examination.This case exemplifies the fact that magnetic resonance spectroscopy provides useful biochemical information in such a clinical setting. |
| Databáze: | OpenAIRE |
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