Detection of Gastrointestinal Nematode Populations Resistant to Albendazole and Ivermectin in Sheep

Autor:	Pedro Mendoza de Gives, David E. Reyes-Guerrero, Gabriel Ramírez-Vargas, Jaime Mondragón-Ancelmo, Amairany Emithziry Ariza-Román, María Eugenia López-Arellano, Fabio Napolitano, Agustín Olmedo-Juárez
Rok vydání:	2019
Předmět:	sheep Veterinary medicine 030231 tropical medicine Drug resistance Biology Group A Article benzimidazole 030308 mycology & parasitology Albendazole ivermectin 03 medical and health sciences 0302 clinical medicine Ivermectin lcsh:Zoology medicine Helminths lcsh:QL1-991 Anthelmintic gastrointestinal nematodes 0303 health sciences lcsh:Veterinary medicine General Veterinary biology.organism_classification Multiple drug resistance Nematode anthelminthic resistance lcsh:SF600-1100 Animal Science and Zoology medicine.drug
Zdroj:	Animals Volume 9 Issue 10 Animals : an Open Access Journal from MDPI Animals, Vol 9, Iss 10, p 775 (2019)
ISSN:	2076-2615
Popis:	Gastrointestinal parasite infections represent a major welfare problem in small ruminants reared in extensive systems, which may be exacerbated by anthelmintic resistance. Therefore, we aimed to study the efficacy of albendazole and ivermectin in sheep. Eighty-six animals were selected from commercial farms in the temperate area of the State of Mexico at the age of seven months. These animals were randomly distributed into three groups: Group A, treated with albendazole, Group I, treated with ivermectin and Group C, left untreated. Faecal samples were collected before the anthelmintic was administered and 15 days post-treatment. Both Group A and Group I displayed a significant decrease of faecal egg counts when pre- and post-treatment values were compared (p = 0.003 and p = 0.049, respectively), and a significantly lower faecal egg count when compared with Group C after the treatment (p < 0.05). However, the faecal egg count reduction test showed that gastrointestinal nematodes (GIN) developed anthelmintic resistance to both albendazole and ivermectin. The results of the polymerase chain reaction (PCR) allowed the identification of Cooperia spp., and Trichostrongylus colubriformis. The allele-specific PCR results confirmed that T. colubriformis was resistant to albendazole. In conclusion, this study showed the presence of resistant GIN to albendazole and ivermectin in sheep reared in Mexican temperate zones. Therefore, nematode infections should be systematically monitored in order to implement integrated management strategies to prevent the spread of anthelmintic resistance.
Databáze:	OpenAIRE
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