| Popis: |
In previous publications we reported on quantity, acid number, and spreading index of the ether-soluble material on the surface of healthy human skin, as well as on the corresponding findings obtained at the base of the stratum corneum (1-4). This deeper level, the “barrier zone” or “stratum conjunctum” of Szakall, was made accessible by removal of the overlying horny layers by means of the stripping method (5-8). In agreement with the observations of Szakall we found a larger amount of lipids in the samples collected from the unstripped skin surface than in the samples collected after stripping (4, 9). The acid number was likewise higher for the lipids obtained from the surface than for those obtained from the barrier zone at the corresponding site. In a limited number of patients with psoriasis, however, this ratio was “reversed, in that the acid number found at the lower level exceeded the acid number for the lipids found on the unstripped surface (4). More recently, many additional investigations in psoriatics have substantiated the earlier preliminary observations. A presentation of all findings obtained to date is the object of this report. |
