Studies on the absorption of choline chloride
| Autor: | H.M. Hines, Carl C. Riedesel |
|---|---|
| Rok vydání: | 1953 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty medicine.drug_class Antibiotics Absorption (skin) Metabolism Small intestine Choline Intestines chemistry.chemical_compound Enzyme Endocrinology medicine.anatomical_structure chemistry Biochemistry Internal medicine medicine Incubation Choline chloride |
| Zdroj: | Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 42(9) |
| Popis: | Two possibilities exist for the metabolism of choline. The present study was undertaken to clarify the manner in which orally ingested choline disappears from the intestine of the rat. It was found that choline disappears from the intestine of the rat at a very constant rate, in a manner suggesting enzymatic absorption. Incubation of choline with intestinal homogenate for the same length of time as reuired for 39 per cent absorption (two hours) did not result in any decrease of choline concentration. When the intestinal bacteria were suppressed by means of antibiotics in the diet, choline disappeared at the same rate as in the non‐treated control rats. It is concluded that choline is absorbed unchanged from the small intestine, and that intestinal bacteria play only a minor role, if any, in its disappearance. |
| Databáze: | OpenAIRE |
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