Treatment of toxoplasmosis: Current options and future perspectives
| Autor: | Tijana Štajner, Sorya Belaz, Neda Konstantinović, Florence Robert-Gangneux, Hélène Guegan |
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| Přispěvatelé: | University of Belgrade [Belgrade], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Jonchère, Laurent, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Epidemiology business.industry 030231 tropical medicine MEDLINE 030108 mycology & parasitology medicine.disease Toxoplasmosis Article 3. Good health lcsh:Infectious and parasitic diseases Clinical trial 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Parasitic disease [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology medicine [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Parasitology lcsh:RC109-216 Intensive care medicine business |
| Zdroj: | Food & Waterborne Parasitology Food and Waterborne Parasitology Food and Waterborne Parasitology, Elsevier, 2019, 15, pp.e00036. ⟨10.1016/j.fawpar.2019.e00036⟩ Food and Waterborne Parasitology, 2019, 15, pp.e00036. ⟨10.1016/j.fawpar.2019.e00036⟩ Food and Waterborne Parasitology, Vol 15, Iss, Pp-(2019) |
| ISSN: | 2405-6766 |
| DOI: | 10.1016/j.fawpar.2019.e00036⟩ |
| Popis: | Toxoplasmosis is a worldwide parasitic disease infecting about one third of humans, with possible severe outcomes in neonates and immunocompromised patients. Despite continuous and successful efforts to improve diagnosis, therapeutic schemes have barely evolved since many years. This article aims at reviewing the main clinical trials and current treatment practices, and at addressing future perspectives in the light of ongoing researches. Highlights • Toxoplasmosis is a widespread zoonosis, which may have an important impact on human and animal health worldwide • Treatment schemes remain unchanged since 20 years, as no new drug has been put recently on the market • Among the few drugs currently available for treatment of toxoplasmosis, none of them is efficient on cysts • Active research to discover new therapeutic targets is ongoing, and promising pathways have been identified, thus paving the way for future drug combinations to eradicate the parasite • Immunomodulatory approaches could add value to prevent relapses in immunocompromised patients, but are still underdeveloped |
| Databáze: | OpenAIRE |
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