Clinical study of invasive pulmonary aspergillosis following influenza A H1N1
| Autor: | Yi Liu, Xiang Wang, Chen Yang, Zuo-Zhou Xie, Zheng-Hua Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China medicine.medical_specialty Pleural effusion Observational Study medicine.disease_cause anti-Aspergillus treatment Gastroenterology Aspergillus fumigatus Galactomannan chemistry.chemical_compound Influenza A Virus H1N1 Subtype Internal medicine Influenza Human medicine Influenza A virus Humans Prospective Studies alveolar lavage fluid Prospective cohort study skin and connective tissue diseases Aged Retrospective Studies Chi-Square Distribution medicine.diagnostic_test biology business.industry invasive pulmonary aspergillosis H1N1 Retrospective cohort study General Medicine Middle Aged biology.organism_classification medicine.disease respiratory tract diseases Bronchoalveolar lavage chemistry galactomannan Female Pulmonary Aspergillosis Tomography X-Ray Computed business Bronchoalveolar Lavage Fluid Chi-squared distribution Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | This study to analyze the clinical characteristics of patients with invasive pulmonary aspergillosis (IPA) following influenza A (H1N1) infection. We retrospectively analyzed 10 cases with IPA following H1N1 infection. The clinical manifestations, laboratory examination results, chest computed tomography, and treatments were analyzed. Clinical manifestations: all 10 cases had typical flu-like symptoms at the onset of the disease, among which 7 patients developed dyspnea in the late stage, and 8 patients had hemoptysis. Laboratory examination: the absolute and percentage of peripheral blood lymphocytes in all 10 patients were declined, among which 5 cases were with decreased CD3+ CD4+ T cells/lymphocytes; 9 cases with increased bronchoalveolar lavage fluid galactomannan; 6 cases with increased serum galactomannan; 1 case with bronchoalveolar lavage fluid cultured aspergillus fumigatus; and 2 cases with aspergillus by second-generation sequencing. Chest computed tomography: all patients showed multiple diffused ground-glass opacities at the beginning, along with linear or reticular interstitial changes. Two cases had multiple subarachnoid nodules with halo signs, 3 cases had consolidation in multiple segments of both lungs, 2 cases had cavities, and 4 cases were with pleural effusion. Treatment: 10 patients were treated with antiviral and anti-Aspergillus drugs after admission. Four patients received respiratory support. All 10 cases were cured and discharged. Early diagnosis of IPA in influenza A (H1N1) patients is the key to successful treatment. |
| Databáze: | OpenAIRE |
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