PEGylated Gold Nanoparticles Target Age-Associated B Cells In Vivo

Autor:	Sandra Hočevar, Viola Puddinu, Laetitia Haeni, Alke Petri-Fink, Julia Wagner, Montserrat Alvarez, Martin James David Clift, Carole Bourquin
Rok vydání:	2022
Předmět:	Mice Cell Survival Polymers General Engineering Animals Metal Nanoparticles General Physics and Astronomy General Materials Science Gold Polyethylene Glycols
Zdroj:	ACS Nano. 16:18119-18132
ISSN:	1936-086X 1936-0851
DOI:	10.1021/acsnano.2c04871
Popis:	Engineered gold nanoparticles (GNPs) have become a useful tool in various therapeutic and diagnostic applications. Uncertainty remains regarding the possible impact of GNPs on the immune system. In this regard, we investigated the interactions of polymer-coated GNPs with B cells and their functions in mice. Surprisingly, we observed that polymer-coated GNPs mainly interact with the recently identified subpopulation of B lymphocytes named age-associated B cells (ABCs). Importantly, we also showed that GNPs did not affect cell viability or the percentages of other B cell populations in different organs. Furthermore, GNPs did not activate B cell innate-like immune responses in any of the tested conditions, nor did they impair adaptive B cell responses in immunized mice. Together, these data provide an important contribution to the otherwise limited knowledge about GNP interference with B cell immune function, and demonstrate that GNPs represent a safe tool to target ABCs
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51d94bf9f5739b27ff39329a27e3cfa https://doi.org/10.1021/acsnano.2c04871 Zobrazit plný text záznamu