Xenogeneic Silencing and Bacterial Genome Evolution: Mechanisms for DNA Recognition Imply Multifaceted Roles of Xenogeneic Silencers
| Autor: | Bo Duan, William Wiley Navarre, Bin Xia, Jun Liu, Pengfei Ding |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DNA
Bacterial Gene Transfer Horizontal Review Bacterial genome size Biology AcademicSubjects/SCI01180 medicine.disease_cause DNA sequencing H-NS/MvaT/Lsr2/Rok 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Bacterial Proteins Transcription (biology) Genetics medicine Humans Gene silencing Gene Silencing Molecular Biology Escherichia coli Gene Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences bacterial genome evolution AcademicSubjects/SCI01130 DNA DNA-Binding Proteins xenogeneic silencer DNA-binding mechanism chemistry Horizontal gene transfer bacterial genomic AT content horizontal gene transfer Genome Bacterial 030217 neurology & neurosurgery |
| Zdroj: | Molecular Biology and Evolution |
| ISSN: | 1537-1719 |
| DOI: | 10.1093/molbev/msab136 |
| Popis: | Horizontal gene transfer (HGT) is a major driving force for bacterial evolution. To avoid the deleterious effects due to the unregulated expression of newly acquired foreign genes, bacteria have evolved specific proteins named xenogeneic silencers to recognize foreign DNA sequences and suppress their transcription. As there is considerable diversity in genomic base compositions among bacteria, how xenogeneic silencers distinguish self- from nonself DNA in different bacteria remains poorly understood. This review summarizes the progress in studying the DNA binding preferences and the underlying molecular mechanisms of known xenogeneic silencer families, represented by H-NS of Escherichia coli, Lsr2 of Mycobacterium, MvaT of Pseudomonas, and Rok of Bacillus. Comparative analyses of the published data indicate that the differences in DNA recognition mechanisms enable these xenogeneic silencers to have clear characteristics in DNA sequence preferences, which are further correlated with different host genomic features. These correlations provide insights into the mechanisms of how these xenogeneic silencers selectively target foreign DNA in different genomic backgrounds. Furthermore, it is revealed that the genomic AT contents of bacterial species with the same xenogeneic silencer family proteins are distributed in a limited range and are generally lower than those species without any known xenogeneic silencers in the same phylum/class/genus, indicating that xenogeneic silencers have multifaceted roles on bacterial genome evolution. In addition to regulating horizontal gene transfer, xenogeneic silencers also act as a selective force against the GC to AT mutational bias found in bacterial genomes and help the host genomic AT contents maintained at relatively low levels. |
| Databáze: | OpenAIRE |
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