Protective effects of hydroalcoholic extracts from an ancient apple variety ‘Mela Rosa dei Monti Sibillini’ against renal ischemia/reperfusion injury in rats
| Autor: | Reza Fayaznia, Sara Hemmati, Hasan Yousefi-Manesh, Samira Shirooie, Mohammad Hossein Asgardoon, Giovanni Caprioli, Filippo Maggi, Seyed Mohammad Nabavi, Mohammad Ghafouri, Joice Guileine Nkuimi Wandjou, Stefano Dall'Acqua, Azita Talebzadeh Bonakdar, Ali Zare Dehnavi, Stefania Sut |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Anti-Inflammatory Agents Down-Regulation Pharmacology 03 medical and health sciences chemistry.chemical_compound Flavonols Nutraceutical Animals Medicine Rats Wistar Renal ischemia reperfusion Inflammation chemistry.chemical_classification 030109 nutrition & dietetics Renal ischemia Plant Extracts business.industry NF-kappa B General Medicine Malondialdehyde medicine.disease Rats 030104 developmental biology chemistry Proanthocyanidin Fruit Malus Reperfusion Injury Kidney Diseases Tumor necrosis factor alpha business Reperfusion injury Food Science |
| Zdroj: | Food & Function. 10:7544-7552 |
| ISSN: | 2042-650X 2042-6496 |
| DOI: | 10.1039/c9fo01635j |
| Popis: | The purpose of this work was to investigate the effect of hydroalcoholic extracts from the peel (APE) and pulp (APP) of a traditional apple variety of central Italy, the ‘Mela Rosa dei Monti Sibillini’, on the damage caused by renal ischemia/reperfusion injury (IRI) in rats. Thirty mg per kg b.w. of the extracts were administered intraperitoneally to male adult Wistar rats 3 days before the induction of IRI by pedicle clamping. A significant decrease in the levels of malondialdehyde (MDA), tumor necrosis factor-α (TNFα), interleukin 1 beta (IL-1β) and nuclear factor-κB (NF-κB) was observed in the groups pre-treated with APE when compared with IRI rats. The chemical composition of APE was determined by HPLC-DAD-MSn highlighting a significant amount of proanthocyanidins (52.9 mg g−1), flavonols (42.27 mg g−1) and dihydrochalcones (11.75 mg g−1). These findings indicated that this ancient apple variety is a promising source of nutraceuticals and functional foods helpful to manage complications of renal disorders. |
| Databáze: | OpenAIRE |
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