Radiation therapy improves survival in patients with testicular diffuse large B-cell lymphoma
Autor: | Nathan Fowler, Fredrick B. Hagemeister, Chelsea C. Pinnix, Jason R. Westin, Francesco Turturro, Jennifer C. Ho, Sattva S. Neelapu, Jay Reddy, Lijuan Deng, Bouthaina S. Dabaja, Grace L. Smith, Ali Mazloom, T.Y. Andraos, Luis Fayad, Pamela K. Allen, Ken H. Young, Maria Alma Rodriguez, Loretta J. Nastoupil, Sarah A. Milgrom, Yasuhiro Oki, L. Jeffrey Medeiros, Wenli Dong |
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Rok vydání: | 2017 |
Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Biopsy medicine.medical_treatment Multimodal Imaging Article Young Adult 03 medical and health sciences 0302 clinical medicine Testicular Neoplasms Internal medicine medicine Humans Combined Modality Therapy Stage (cooking) Young adult Aged Neoplasm Staging Aged 80 and over Univariate analysis Radiotherapy business.industry Hematology Middle Aged medicine.disease Surgery Lymphoma Radiation therapy 030220 oncology & carcinogenesis Rituximab Lymphoma Large B-Cell Diffuse business Diffuse large B-cell lymphoma Biomarkers Follow-Up Studies 030215 immunology medicine.drug |
Zdroj: | Leukemia & Lymphoma. 58:2833-2844 |
ISSN: | 1029-2403 1042-8194 |
Popis: | In 120 Stage I–IV testicular diffuse large B-cell lymphoma (DLBCL) patients treated from 1964 to 2015, we assessed the benefits of prophylactic contralateral testicular radiation (RT) and prophylactic central nervous system (CNS) therapy on overall, progression free, testicular relapse free, and CNS relapse free survival (OS, PFS, TRFS, and CRFS, respectively). Seventy percent of patients received RT, 53% received anthracyclines and rituximab (modern therapy), and 61% received CNS prophylaxis. On univariate analysis RT was associated with improved TRFS, PFS, and trended toward improved OS. On multivariate analysis (MVA), RT was significantly associated with improved OS and PFS; the PFS benefit persisted among patients receiving modern therapy. CNS prophylaxis was associated with improved OS, PFS, and TRFS, but not CRFS on univariate analysis, and was not significant on MVA. RT is associated with improved survival, and should be considered for all testicular DLBCL patients, but additional strategies are needed to prevent CNS relapse. |
Databáze: | OpenAIRE |
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