Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy
| Autor: | Jouko I. T. Isojärvi, Johanna Rättyä, Vilho V. Myllylä, Arto Pakarinen, Mervi Kotila, Jukka Turkka |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
endocrine system diseases medicine.medical_treatment Thyroid Gland Thyrotropin Thyroid Function Tests 0302 clinical medicine 030212 general & internal medicine Oxcarbazepine Triiodothyronine biology Thyroid gamma-Glutamyltransferase Middle Aged 3. Good health medicine.anatomical_structure Carbamazepine Neurology Liver Enzyme Induction Anticonvulsants Thyroid function medicine.drug Adult endocrine system medicine.medical_specialty Adolescent Radioimmunoassay Iodide Peroxidase Thyroglobulin 03 medical and health sciences Sex Factors Thyroid peroxidase Internal medicine medicine Humans Epilepsy business.industry Valproic Acid Thyroxine Endocrinology biology.protein Neurology (clinical) business 030217 neurology & neurosurgery Hormone |
| Zdroj: | Epilepsia. 42(7) |
| ISSN: | 0013-9580 |
| Popis: | Summary: Purpose: Antiepileptic drugs (AEDs) may affect serum thyroid hormone concentrations. This study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), oxcarbazepine (OCBZ), or valproate (VPA) for epilepsy. Methods: Ninety men with epilepsy (40 taking CBZ, 29 taking OCBZ, and 21 taking VPA monotherapy) and 25 control subjects participated in the study. After clinical examination, a blood sample for hormone, γ-glutamyl-transferase (GGT) and antibody (ab) assays was obtained. Results: Serum thyroxine (T4) and free thyroxine (FT4) concentrations were low in men taking CBZ or OCBZ. Forty-five percent of men taking CBZ and 24% of men taking OCBZ had serum T4 and/or FT4 levels below the reference range. However, no correlations were found between T4 or FT4 and GGT concentrations in men taking CBZ or OCBZ. Thirteen percent of men taking CBZ, 17% of men taking OCBZ, and 6% of control men had increased levels of thyroid peroxidase (TPO)-ab and/or thyroglobulin (TG)-ab, but these were not associated with altered serum thyroid hormone concentrations. Serum triiodothyronine and thyrotropin levels in men taking CBZ or OCBZ were normal. In men taking VPA, the concentrations of thyroid hormones, thyrotropin, and antithyroid ab were normal. Conclusions: Serum thyroid hormone concentrations are low in CBZ- or OCBZ-treated men. However, these low levels do not seem to be due to liver enzyme induction or activation of immunologic mechanisms. Therefore, interference with hypothalamic regulation of thyroid function by CBZ and OCBZ seems possible. VPA does not have any significant effects on thyroid function. |
| Databáze: | OpenAIRE |
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