Metabolites of 1,2,3,4‐tetrachlorobenzene in monkey urine
| Autor: | A. Viau, H. Schwartz, Ih Chu, D. C. Villeneuve, F. M. Benoit |
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| Rok vydání: | 1985 |
| Předmět: |
Chromatography
Metabolite Administration Oral Urine Metabolism Chlorobenzenes Toxicology Pollution Gas Chromatography-Mass Spectrometry Acetylcysteine Chlorobenzene metabolism chemistry.chemical_compound Biochemistry chemistry Oral administration Animals Chromatography Thin Layer Benzene Saimiri Chromatography High Pressure Liquid Cysteine Conjugate |
| Zdroj: | Journal of Toxicology and Environmental Health. 15:603-607 |
| ISSN: | 0098-4108 |
| DOI: | 10.1080/15287398509530689 |
| Popis: | [14C(U)]-Labeled 1,2,3,4-tetrachlorobenzene was administered orally to squirrel monkeys. Urine was collected from these animals, pooled and analyzed for metabolites by thin-layer chromatography, high-performance liquid chromatography, and gas chromatography-mass spectroscopy. N-Acetyl-s-(2,3,4,5-tetrachlorophenyl) cysteine was shown to be the major metabolite and accounted for 85% of the radioactivity found in urine. A minor metabolite was identified as 2,3,4,5-tetrachlorophenol. This study demonstrates for the first time that an N-acetyl cysteine conjugate has been isolated and identified as metabolite of a chlorinated benzene. This pattern of chlorobenzene metabolism is significantly different from the one obtained with the rat and rabbit, where tetrachlorophenols constitute the major metabolites. |
| Databáze: | OpenAIRE |
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