Low-Intensity Extracorporeal Shock Wave Therapy Ameliorates the Overactive Bladder: A Prospective Pilot Study

Autor: Kun-Ling Lin, Shu-Mien Chuang, Li-Wen Liu, Cheng-Yu Long, Yung-Chin Lee, Jian-He Lu, Mei-Chen Shen, Kuang-Shun Chueh, Yung-Shun Juan, Wei-Chiao Chen
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Extracorporeal Shockwave Therapy
medicine.medical_specialty
Article Subject
medicine.medical_treatment
Urinary system
Urinary Bladder
030232 urology & nephrology
Urology
Urination
Pilot Projects
urologic and male genital diseases
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Young Adult
0302 clinical medicine
Surveys and Questionnaires
medicine
Nocturia
Humans
Prospective Studies
Prospective cohort study
Suprapubic cystostomy
Aged
030219 obstetrics & reproductive medicine
Urinary bladder
General Immunology and Microbiology
business.industry
Urinary Bladder
Overactive
Therapeutic effect
General Medicine
Middle Aged
medicine.disease
female genital diseases and pregnancy complications
medicine.anatomical_structure
Overactive bladder
Extracorporeal shockwave therapy
Clinical Study
Quality of Life
Medicine
Female
medicine.symptom
business
Zdroj: BioMed Research International
BioMed Research International, Vol 2020 (2020)
ISSN: 2314-6141
2314-6133
Popis: Objective. In the present clinical trial, we evaluated the therapeutic effects of low-intensity extracorporeal shockwave therapy (LiESWT) on overactive bladder (OAB). Methods. Female subjects with ages of 20-75 years and who have been clinically diagnosed with OAB were included in the study. The LiESWT (DUOLITH SD1 T-TOP, AG) applicator was placed on the suprapubic skin area and applied with an intensity of 0.25 mJ/mm2, 3000 pulses, and 3 pulses/second. To assess the therapeutic efficacy, all subjects were required to complete the validated OAB symptoms and life bothersome questionnaires, 3-day urinary diary, uroflowmetry, and post-voided residual urine (PVR) measurement at 4 weeks of LiESWT (W4), 8 weeks of LiESWT (W8), 1-month follow-up (F1), and 3-month follow-up (F3) after LiESWT. Result. 82 subjects with the mean age of 56.5±1.2 years were enrolled. The questionnaire scores were significantly improved at W4, W8, F1, and F3 as compared to baseline data (W0). At W8, the mean values of functional bladder capacity were meaningfully increased. According to the 3-day urinary diary, daytime frequency, urgency, and nocturia were significantly decreased. The uroflowmetry results showed that the mean voided urine volume and the maximal flow rate (Qmax) were noticeably increased. PVR volume was also significantly decreased. Conclusions. The data demonstrated that 8-week LiESWT ameliorated the OAB symptoms, promoted the uroflow parameters, and improved the quality of life (QoL) in OAB patients, suggesting that LiESWT might serve as an alternative noninvasive therapy for OAB.
Databáze: OpenAIRE
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