Urokinase receptor is up-regulated in endothelial cells and macrophages associated with fibrinoid deposits in the human placenta
| Autor: | B. Schnack Nielsen, Leif R. Lund, P. Kaufmann, C. Pierleoni, Mario Castellucci |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
CD31
Adult Blood Platelets medicine.medical_specialty Pathology medicine.medical_treatment Placenta Receptors Cell Surface Platelet Glycoprotein GPIIb-IIIa Complex Fibrin Receptors Urokinase Plasminogen Activator Pregnancy Zymogen Internal medicine Fibrinolysis von Willebrand Factor medicine Humans Platelet Endothelium Receptor biology Chemistry Macrophages Obstetrics and Gynecology Up-Regulation Urokinase receptor Platelet Endothelial Cell Adhesion Molecule-1 medicine.anatomical_structure Endocrinology Reproductive Medicine biology.protein Female Biomarkers Developmental Biology |
| Zdroj: | Placenta. 24(6) |
| ISSN: | 0143-4004 |
| Popis: | Clearance of fibrin deposits within the human placenta is an ongoing process during normal placental development. Plasminogen is a circulating fibrinolytic protease zymogen activated in situ by plasminogen activators. We have previously reported that the receptor for urokinase plasminogen activator (uPAR) is expressed by cells either covering or enmeshed within the perivillous fibrinoid deposits. Whereas these cells seemed likely to be trophoblasts, a definitive identification was lacking, and this question is central to the understanding of the cellular mechanisms directing fibrinolysis in the placenta. In this study we have performed immunohistochemical co-localization studies and found that the uPAR-positive cells covering fibrinoid deposits are immunoreactive for CD31 and vWF, indicating that they are actually endothelial cells. In addition, we found that perivillous fibrinoid deposits not covered with uPAR-positive endothelial cells were covered with platelets identified by integrin α IIb β 3 -immunoreactivity. Also surprisingly, the uPAR-positive cells enmeshed within fibrinoid deposits express a cell specific marker indicating that they are macrophages. Both uPAR-positive cell populations also express uPA immunoreactivity. Taken together, the data suggest that both fibrinoid-covering endothelial cells and fibrinoid-enmeshed macrophages can participate in the clearance process of perivillous fibrinoid deposits formed in the human placenta. |
| Databáze: | OpenAIRE |
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