Acetaldehyde, a metabolite of ethanol, activates the hypothalamic-pituitary-adrenal axis in the rat
| Autor: | Kiyoshi Ameno, Hiroshi Kinoshita, Iwao Jiri, David J. Roberts, Toni L. Coventry, David S. Jessop, Michael S. Harbuz, David P. Finn |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Hypothalamo-Hypophyseal System medicine.medical_specialty Vasopressin Pro-Opiomelanocortin Corticotropin-Releasing Hormone Metabolite Pituitary-Adrenal System Aldehyde dehydrogenase Acetaldehyde Rats Sprague-Dawley chemistry.chemical_compound Anterior pituitary Pituitary Gland Anterior Internal medicine medicine Animals RNA Messenger Ethanol metabolism Ethanol biology Chemistry Central Nervous System Depressants General Medicine Rats Arginine Vasopressin medicine.anatomical_structure Endocrinology Cyanamide biology.protein Corticosterone Paraventricular Hypothalamic Nucleus |
| Zdroj: | Alcohol and Alcoholism. 36:59-64 |
| ISSN: | 1464-3502 |
| Popis: | — Cyanamide is a potent inhibitor of aldehyde dehydrogenase (ALDH: EC 1.2.1.3) used in the treatment of alcoholics. In the presence of ethanol, cyanamide causes an accumulation of acetaldehyde, a highly toxic metabolite of ethanol, with unpleasant side-effects. A similar accumulation is seen in some Oriental people with low ALDH activity. We have investigated the effects of ethanol and cyanamide administration on the activation of the hypothalamic–pituitary–adrenal (HPA) axis using in situ hybridization histochemistry and radioimmunoassay. Ethanol plus cyanamide resulted in a significant increase in corticotrophin-releasing factor and arginine vasopressin mRNA in the paraventricular nucleus, and pro-opiomelanocortin mRNA in the anterior pituitary. Plasma corticosterone concentrations were also significantly elevated following ethanol plus cyanamide administration. The blood concentration of acetaldehyde in the ethanol plus cyanamide group increased significantly. These results suggest that acetaldehyde, induced by blocking ethanol metabolism, is able to activate the HPA axis operating through a central mechanism. |
| Databáze: | OpenAIRE |
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