Miconazole therapy for systemic candidiasis in a conjoined (Siamese) twin and a premature newborn
| Autor: | Devinder R. Chopra, James P. Sung, Ernest B. Haws, Jan G. Grendahl, Krishna Rajani |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Miconazole Infant Premature Diseases Sepsis Oliguria Candida albicans medicine Humans Twins Conjoined Respiratory distress business.industry Organ dysfunction Candidiasis Imidazoles Infant Newborn Infant Metabolic acidosis General Medicine medicine.disease Anesthesia Surgery Anuria Systemic candidiasis medicine.symptom business medicine.drug |
| Zdroj: | American journal of surgery. 138(5) |
| ISSN: | 0002-9610 |
| Popis: | A 2.5 kg thoracopagus (Siamese) twin and a 0.73 kg premature newborn developed systemic candidiasis and were treated with intravenous miconazole. The conjoined twin was in a state of severe metabolic acidosis, respiratory distress, jaundice, anuria, abdominal distension, and shock. The 0.73 kg premature infant was also in a state of severe metabolic acidosis, respiratory distress, and oliguria. Miconazole was used in this desperate situation for the treatment of life-threatening candidiasis. Both infants responded well to treatment and recovered. All parameters of their diseases improved during therapy despite pre-existing multiple organ dysfunction. Miconazole can be a safe alternative to amphotericin B for the treatment of systemic candidiasis in neonatal infants, including those with impaired renal function. |
| Databáze: | OpenAIRE |
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