Neutrophils self-limit swarming to contain bacterial growth in vivo
| Autor: | Teresa K. Tarrant, Sarah Eickhoff, Konrad Knöpper, Eduardo Reátegui, Maximilian W. Epple, Katharina M. Glaser, Ralf Baumeister, Matthias Gunzer, Wolfgang Kastenmüller, Ronald N. Germain, Daniel Irimia, Michael Mihlan, Tim Lämmermann, Korbinian Kienle |
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| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Cell signaling Multidisciplinary Innate immune system biology Neutrophils Chemistry Medizin Swarming (honey bee) Chemotaxis Inflammation biology.organism_classification Article Cell aggregation 3. Good health Cell biology 03 medical and health sciences 0302 clinical medicine medicine medicine.symptom Signal transduction 030217 neurology & neurosurgery Bacteria 030304 developmental biology |
| Zdroj: | Science |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Stopping the swarmNeutrophils play a major role in the early immune response and are recruited in large numbers into inflamed and infected tissues. By secreting chemoattractants that bind G protein–coupled receptors (GPCRs) on neighboring cells, neutrophils coordinate their behavior as a swarm. Less clear is how this auto-amplifying swarming activity is ultimately turned off. Kienleet al.show that desensitization of these GPCRs by the same chemoattractants by GPCR-kinase 2 (GRK2) is one way in which these swarms are shut down (see the Perspective by Rocha-Gregg and Huttenlocher). Unexpectedly, mice with GRK2-deficient neutrophils showed impaired rather than enhanced bacterial clearance. The heightened scanning ability of GRK2-deficient neutrophils may come at the cost of suboptimal phagocytosis and containment of bacteria.Science, abe7729, this issue p.eabe7729; see also abj3065, p.1262 |
| Databáze: | OpenAIRE |
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