Cytokine profiles in 1-year-old very low birth weight infants after enteral glutamine supplementation in the neonatal periode
| Autor: | Edward E. S. Nieuwenhuis, Ruurd M. van Elburg, Anemone van den Berg, Annelies van Zwol, Willem P. F. Fetter, Jos W. R. Twisk |
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| Přispěvatelé: | Pediatrics, Pediatric Surgery, Pediatric surgery, EMGO - Lifestyle, overweight and diabetes, ICaR - Ischemia and repair, Methodology and Applied Biostatistics, EMGO+ - Lifestyle, Overweight and Diabetes, Other departments |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Glutamine Birth weight Immunology Physiology Communicable Diseases Enteral administration Dermatitis Atopic Cohort Studies Atopy Young Adult Enteral Nutrition Th2 Cells SDG 3 - Good Health and Well-being Humans Infant Very Low Birth Weight Immunology and Allergy Medicine business.industry Incidence Incidence (epidemiology) Infant Newborn Infant Atopic dermatitis Th1 Cells medicine.disease Interleukin 10 Low birth weight Treatment Outcome Parenteral nutrition Pediatrics Perinatology and Child Health Cytokines Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Pediatric Allergy and Immunology, 20, 467-470. Blackwell Publishing Pediatric and Allergy Immunology, 20(5), 467-470. Blackwell Munksgaard Pediatric Allergy and Immunology, 20(5), 467-470. Blackwell Munksgaard Pediatric allergy and immunology, 20(5), 467-470. Blackwell Munksgaard van Zwol, A, van den Berg, A, Nieuwenhuis, E E S, Twisk, J W R, Fetter, W P F & van Elburg, R M 2009, ' Cytokine profiles in 1-yr-old very low-birth-weight infants after enteral glutamine supplementation in the neonatal period ', Pediatric and Allergy Immunology, vol. 20, no. 5, pp. 467-470 . https://doi.org/10.1111/j.1399-3038.2008.00813.x van Zwol, A, van den Berg, A, Nieuwenhuis, E E S, Twisk, J W R, Fetter, W P F & van Elburg, R M 2009, ' Cytokine profiles in 1-yr-old very low-birth-weight infants after enteral glutamine supplementation in the neonatal period ', Pediatric Allergy and Immunology, vol. 20, no. 5, pp. 467-470 . https://doi.org/10.1111/j.1399-3038.2008.00813.x |
| ISSN: | 0905-6157 |
| DOI: | 10.1111/j.1399-3038.2008.00813.x |
| Popis: | In a previous study, we found that glutamine-enriched enteral nutrition in 102 very low-birth-weight (VLBW) infants decreased both the incidence of serious neonatal infections and atopic dermatitis during the first year of life. The aims of this follow-up study were to determine whether these beneficial effects are attended by changes in Th(1) and Th(2) cytokine profiles at age 1 yr. Furthermore, we studied changes in cytokine profiles during the first year of life in these VLBW infants. In total, 89 infants were eligible for the follow-up study (12 died, 1 exclusion due to a chromosomal abnormality). Th(1) (IFN-gamma, TNF- alpha and IL-2) and Th(2) cytokine (IL-10, IL-5, and IL-4) profiles following in vitro whole blood stimulation were measured at 1 yr. Cytokine profiles were measured in 59/89 (66%) infants. Glutamine-enriched enteral nutrition in neonatal period did not influence cytokine profiles at 1 yr. Cytokine profiles were not different in infants with and without allergic or infectious diseases. The beneficial effect of glutamine-enriched enteral nutrition on the incidence of serious neonatal infections and atopic dermatitis during the first year of life is not related to changes in the Th(1) and Th(2) cytokine profiles. Both Th(1) and Th(2) cytokine profiles increased during the first year of life in this cohort of VLBW infants. |
| Databáze: | OpenAIRE |
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