HIV-1 Tropism and Liver Fibrosis in HIV–HCV Co-Infected Patients
| Autor: | Florence Abravanel, Stéphanie Raymond, Elodie Pambrun, Maria Winnock, Philippe Bonnard, Philippe Sogni, Pascale Trimoulet, François Dabis, Dominique Salmon-Ceron, Jacques Izopet, ANRS CO13 HEPAVIH Study Group |
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| Přispěvatelé: | Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Maladies infectieuses et tropicales [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), CHU de Bordeaux Pellegrin [Bordeaux], Microbiologie Fondamentale et Pathogénicité (MFP), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Service Maladies infectieuses et tropicales [AP-HP Hôpital Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Pagès, Nathalie |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Liver Cirrhosis
Male viruses [SDV]Life Sciences [q-bio] MESH: HIV Infections / complications HIV Infections Hepacivirus medicine.disease_cause MESH: Antiretroviral Therapy Highly Active Fibrosis Antiretroviral Therapy Highly Active MESH: Hepatocytes / metabolism Multidisciplinary Coinfection virus diseases Hepatitis C Middle Aged MESH: Hepatocytes / pathology MESH: RNA Viral / biosynthesis [SDV] Life Sciences [q-bio] Disease Progression RNA Viral Infectious diseases Medicine Female HIV clinical manifestations Research Article Adult Receptors CXCR4 Viral Entry Receptors CCR5 Hepatitis C virus Science Gastroenterology and Hepatology Viral diseases Biology Antiviral Agents Microbiology Virus MESH: HIV Infections / pathology MESH: Receptors CXCR4 / metabolism Virology Hepatic Stellate Cells medicine HIV tropism Humans MESH: HIV Infections / virology Tropism Aged HIV MESH: Receptors CCR5 / metabolism MESH: Adult medicine.disease MESH: Liver Cirrhosis / virology MESH: Hepatocytes / virology Viral Tropism MESH: Hepatitis C / virology Immunology HIV-1 Hepatocytes Tissue tropism MESH: Hepatitis C / pathology Viral Transmission and Infection MESH: Liver Cirrhosis / drug therapy |
| Zdroj: | PLoS ONE PLoS ONE, 2012, 7 (11), pp.e50289. ⟨10.1371/journal.pone.0050289⟩ PLoS ONE, Vol 7, Iss 11, p e50289 (2012) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0050289⟩ |
| Popis: | Background and aimsHepatic stellate cells, the major producers of extracellular matrix in the liver, and hepatocytes bear CXCR4 and CCR5, the two main co-receptors for entry of the human immunodeficiency virus (HIV). In vitro studies suggest that HIV-envelope proteins can modulate the replication of hepatitis C virus (HCV) and fibrogenesis. We investigated the influence of HIV tropism on liver fibrosis and the concentration of HCV RNA in HIV-HCV co-infected patients.MethodsWe used a phenotypic assay to assess HIV tropism in 172 HCV-HIV co-infected patients: one group (75 patients) had mild fibrosis (score ≤F2) and the other (97 patients) had severe fibrosis (score >F2). We also assessed the relationship between HIV tropism and HCV RNA concentration in all these patients. We also followed 34 of these patients for 3 years to determine the evolution of HIV tropism and liver fibrosis, estimated by liver stiffness.ResultsInitially, most patients (91.8%) received a potent antiretroviral therapy. CXCR4-using viruses were found in 29% of patients. The only factor associated with a CXCR4-using virus infection in multivariate analysis was the nadir of CD4 cells: ConclusionsThe presence of CXCR4-using viruses in patients receiving a potent antiretroviral therapy does not influence HCV RNA concentration or liver fibrosis. |
| Databáze: | OpenAIRE |
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