Galantamine Response Associates with Agitation and the Prefrontal Cortex in Patients with Alzheimer’s Disease
| Autor: | Nobutaka Hattori, Atsushi Nakanishi, Akimitsu Suda, Sachiko Nakayama, Yumiko Motoi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Behavioral Symptoms Disease Single-photon emission computed tomography 03 medical and health sciences 0302 clinical medicine Cost of Illness Alzheimer Disease Internal medicine mental disorders Galantamine medicine Humans Dementia 030212 general & internal medicine Prefrontal cortex Aged Tomography Emission-Computed Single-Photon Psychotropic Drugs medicine.diagnostic_test Aggression business.industry General Neuroscience Brain General Medicine Caregiver burden Mental Status and Dementia Tests medicine.disease Psychiatry and Mental health Clinical Psychology Treatment Outcome Caregivers Cerebral blood flow Female Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Alzheimer's Disease. 57:267-273 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-160902 |
| Popis: | Behavioral and psychological symptoms of dementia (BPSD) occur in up to 80% of AD patients and represent one of the largest factors contributing to caregiver burden. To analyze the effect of galantamine on BPSD and caregiver burden, we treated a total of 50 patients with mild AD for 12 weeks and evaluated them using the Neuropsychiatric Inventory (NPI) and Japanese version of the Zarit Caregiver Burden Interview (ZBI). We also performed regional cerebral blood flow single photon emission computed tomography (rCBF SPECT) at baseline using three-dimensional sterotatic surface projections. Total NPI and ZBI scores did not significantly change after 12-week galantamine treatment. To identify the characteristics of patients who showed improvement after galantamine treatment, we divided patients into two groups, those with and those without sub-items on the NPI. Patients with aggression showed improvement in ZBI scores (p |
| Databáze: | OpenAIRE |
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