Matrix metalloproteinases in patients with osteoarthritis of the hip
| Autor: | Kensaku Masuhara, Tsuyoshi Nakai, Nobuhiko Sugano, Y. Sasaguri, S. Bak Lee, Takahiro Ochi |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Blotting Western Urology Connective tissue Osteoarthritis Matrix metalloproteinase Osteoarthritis Hip Pathogenesis Arthropathy medicine Humans Orthopedics and Sports Medicine Fibroblast Cells Cultured Aged Original Paper business.industry Fibroblasts medicine.disease Acetabulum Matrix Metalloproteinases Radiography medicine.anatomical_structure Matrix Metalloproteinase 9 Orthopedic surgery Matrix Metalloproteinase 2 Female Matrix Metalloproteinase 3 Surgery Matrix Metalloproteinase 1 business |
| Zdroj: | International Orthopaedics. 24:92-96 |
| ISSN: | 1432-5195 0341-2695 |
| DOI: | 10.1007/s002640000110 |
| Popis: | In 78 patients undergoing a total hip replacement we examined the production of matrix metalloproteinases (MMP) by the fibroblasts from the connective tissue of the acetabulum; we then correlated these findings with clinical and radiological characteristics of the same patients. In 53 patients only MMP-2 was produced; in 15 cases MMP-1, -2 and -3 were present; and in 10 cases not only MMP-1, -2, -3 but also MMP-9. Significant differences among the clinical and radiological parameters were found in the 3 subsets. A positive correlation between the production of MMP-9 and a rapid destruction of the hip joint was found. |
| Databáze: | OpenAIRE |
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