Vibrational Spectroscopy: A Valuable Screening and Diagnostic Tool for Obstetric Disorders?
| Autor: | Margery Morgan, Cerys A Jenkins, Jayne Bowden, Catherine A. Thornton, Oliver Richards, Helena Griffiths, Sharon Jones, Manju Nair, P. R. Dunstan, Edyta Paczkowska, Annettee Nakimuli, Tanya Thomas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Low resource diagnosis Disease Review Molecular Fingerprint lcsh:Gynecology and obstetrics World health Global Women's Health preeclampsia fourier-transform infrared spectroscopy (FTIR) 03 medical and health sciences 0302 clinical medicine medicine Medical history Intensive care medicine lcsh:RG1-991 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine Obstetric disorders business.industry screening lcsh:Women. Feminism vibrational spectroscopy Molecular analysis Raman spectroscopy Community setting gestational diabetes business lcsh:HQ1101-2030.7 |
| Zdroj: | Frontiers in Global Women's Health, Vol 1 (2021) Frontiers in Global Women's Health |
| ISSN: | 2673-5059 |
| DOI: | 10.3389/fgwh.2020.610582/full |
| Popis: | Preeclampsia (PE) is a common obstetric disorder typically affecting 2–8% of all pregnancies and can lead to several adverse obstetric outcomes for both mother and fetus with the greatest burden of severe outcomes in low middle-income countries (LMICs), therefore, screening for PE is vital. Globally, screening is based on maternal characteristics and medical history which are nonspecific for the disorder. In 2004, the World Health Organization acknowledged that no clinically useful test was able to predict the onset of PE, which prompted a universal search for alternative means of screening. Over the past decade or so, emphasis has been placed on the use of maternal characteristics in conjunction with biomarkers of disease combined into predictive algorithms, however these are yet to transition into the clinic and are cost prohibitive in LMICs. As a result, the screening paradigm for PE remains unchanged. It is evident that novel approaches are needed. Vibrational spectroscopy, specifically Raman spectroscopy and Fourier-transform infrared spectroscopy (FTIR), could provide better alternatives suited for implementation in low resource settings as no specialized reagents are required for conventional approaches and there is a drive to portable platforms usable in both urban and rual community settings. These techniques are based on light scattering and absorption, respectively, allowing detailed molecular analysis of samples to produce a unique molecular fingerprint of diseased states. The specificity of vibrational spectroscopy might well make it suited for application in other obstetric disorders such as gestational diabetes mellitus and obstetric cholestasis. In this review, we summarize current approaches sought as alternatives to current screening methodologies and introduce how vibrational spectroscopy could offer superior screening and diagnostic paradigms in obstetric care. Additionally, we propose a real benefit of such tools in LMICs where limited resources battle the higher prevalence of obstetric disorders. |
| Databáze: | OpenAIRE |
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