Lymphocyte subpopulations and corticosteroid treatment in patients with pertussis
| Autor: | Marwan Issi, Carmen Sampietro, Donato Torre, D. Rossi, Franco Maggiolo, G. Ingrosso |
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| Rok vydání: | 1986 |
| Předmět: |
Bordetella pertussis
Cellular immunity biology business.industry Toxin Whooping Cough Corticosteroid treatment biology.organism_classification medicine.disease_cause Lymphocyte subpopulations Immunity Adrenal Cortex Hormones Pediatrics Perinatology and Child Health Immunology Medicine Humans In patient Lymphocytes Respiratory system business Child |
| Zdroj: | American journal of diseases of children (1960). 140(11) |
| ISSN: | 0002-922X |
| Popis: | Sir .—Immunity in pertussis has not yet been clarified; local immunity probably plays an important role, as Bordetella pertussis causes a noninvasive infection that is restricted to the ciliated respiratory epithelial cells. On the other hand, a toxin produced by B pertussis , lymphocytosispromoting factor, is responsible for systemic manifestations. Hewlett et al 1 showed that B pertussis causes an impairment of cell-mediated immunity in children that is reversible with recovery. The use of corticosteroids in pertussis remains controversial; Zoumboulakis et al 2 and Chandra et al 3 demonstrated a beneficial effect of corticosteroids in reducing the severity and the number of attacks of whooping; however, corticosteroids can impair cellular immunity and could lead to severe complications. Patients and Methods .—To analyze the role of B pertussis and corticosteroid treatment, we examined T-lymphocyte subpopulations of 11 patients with pertussis. Patients were admitted to our division with the diagnosis of pertussis based |
| Databáze: | OpenAIRE |
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