Relationships between plasma apelin and adiponectin with normal weight obesity, body composition, and cardiorespiratory fitness in working adults
| Autor: | Greg S. Martin, Thomas R. Ziegler, Emory Hsu, Moriah P. Bellissimo, Kirk Easley, Jessica A. Alvarez, Li Hao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Adipose Adipokine Adipose tissue 030209 endocrinology & metabolism Body fat percentage Diseases of the endocrine glands. Clinical endocrinology Fat distribution 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Fitness Myokine medicine 030212 general & internal medicine Obesity phenotype Adiponectin business.industry nutritional and metabolic diseases Cardiorespiratory fitness RC648-665 Apelin Normal weight obesity Cytokines Metabolic business Research Paper |
| Zdroj: | Journal of Clinical & Translational Endocrinology, Vol 24, Iss, Pp 100257-(2021) Journal of Clinical & Translational Endocrinology |
| ISSN: | 2214-6237 |
| DOI: | 10.1016/j.jcte.2021.100257 |
| Popis: | Background: A significant proportion of adults have normal weight obesity (NWO), defined as a normal body mass index (BMI) but disproportionately high body fat percentage. Individuals with NWO may have increased risk of cardiometabolic disorders and lower exercise tolerance, but it is unclear if this obesity phenotype is linked with dysregulated production of adipokines or myokines such as adiponectin and apelin, respectively. Methods: This cross-sectional, secondary analysis included 177 working adults (mean age 49.6 ± 9.9 yrs, 64% female). Plasma high-molecular weight adiponectin and apelin levels were measured by ELISA. Body composition and fat distribution were assessed using dual energy X-ray absorptiometry. Exercise tolerance (VO2 maximum) was determined by treadmill testing. NWO was defined as a BMI 30% for women or >23% for men. Participants were categorized as lean, NWO, or overweight-obese. Results: A total of 14.7% of subjects were categorized as lean, 23.7% as having NWO, and 61.6% as having overweight-obesity. Plasma adiponectin levels were elevated in the overweight-obesity group (P 0.05). Adiponectin concentrations were inversely associated with BMI, fat mass, fat mass percent, visceral fat, and trunk to leg fat ratio and positively associated with leg fat mass (all P |
| Databáze: | OpenAIRE |
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