Characterization of Regulatory T-Cells in Multiple Sclerosis Patients Treated with Interferon Beta-1a
| Autor: | Ali Ganji, Keyvan Ghasami, Ghasem Mosayebi, Sara Zahedi, Mohsen Ebrahimimonfared, Parisa Nourbakhsh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Population T-Lymphocytes Regulatory 03 medical and health sciences 0302 clinical medicine Immune system Multiple Sclerosis Relapsing-Remitting Interferon Medicine Humans IL-2 receptor education Pharmacology education.field_of_study business.industry General Neuroscience Multiple sclerosis Interferon beta-1a Interleukin-2 Receptor alpha Subunit FOXP3 Forkhead Transcription Factors medicine.disease 030104 developmental biology Cytokine Case-Control Studies Immunology CD4 Antigens business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | CNSneurological disorders drug targets. 17(2) |
| ISSN: | 1996-3181 |
| Popis: | Background: Regulatory T-Cells (Treg Cells), as one of the immune system components, have been highly effective in the autoimmune diseases prevention, particularly multiple sclerosis (MS). Cytokine-based therapies such as interferon beta-1a (IFN-β1a) is a common drug in MS treatment; however, its exact mechanisms are insufficiently described. Objective: Therefore, the goal of this study was to evaluate the in vivo impact of IFN-β1a on the Treg Cells in MS. Methods: In this case-control study, Treg Cells were analysed by flowcytometry in IFN-β1a-treated relapsing-remitting MS (RRMS) in comparison with new cases of MS and healthy subjects. Results: The frequency of Treg Cells in the IFN-β1a treated-RRMS was increased compared to the new MS cases (P < 0.05). Furthermore, the MFIs of the CD4 and CD25 in T-Cells were significantly reduced in new cases of MS and IFN-β1a-treated RRMS than the control subjects (P < 0.05). Additionally, the FoxP3 MFIs in CD4 + CD25 + T-Cells of IFN-β1a-treated RRMS were significantly lower than the new cases of MS. Conclusion: Overall, the present study indicated that IFN-β1a as an immunomodulatory drug led to an enhancement in Treg Cells population without CD4, CD25, and FoxP3 molecules upregulation in Treg Cells. |
| Databáze: | OpenAIRE |
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