Development of a potassium-specific adsorbent for direct hemoperfusion
| Autor: | Yoshiaki Okada, Tadashi Miyahara, Chikanori Terai, Ikuo Tanaka, Shuhei Nakaji, Shunsuke Matsushima, Shoichiro Shimizu |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Hyperkalemia
Platelet Aggregation medicine.medical_treatment Sodium Potassium Biomedical Engineering Medicine (miscellaneous) chemistry.chemical_element Bioengineering Calcium In Vitro Techniques Biomaterials Hemoglobins Dogs medicine Animals Magnesium Cation Exchange Resins Serum Albumin Calcium metabolism Chromatography Platelet Count General Medicine Blood Proteins Hemoperfusion Disease Models Animal Cholesterol Treatment Outcome Activated charcoal Biochemistry chemistry medicine.symptom |
| Zdroj: | Artificial organs. 20(11) |
| ISSN: | 0160-564X |
| Popis: | Direct hemoperfusion (DHP) over an exchange resin for sodium is capable of rapidly lowering an elevated serum potassium level but has not been used clinically because of subsequent electrolyte abnormalities. After the completion of detailed in vitro studies, we developed a sodium/calcium/magnesium exchange resin mixture specifically to remove potassium from the blood. The mixture, which consisted of exchange resins for sodium (48%), calcium (48%), and magnesium (4%), gave the most satisfactory results in vitro. DHP through these resin-mixture columns for 2 h reduced elevated plasma potassium levels (6.7 +/- 1.1 to 3.5 +/- 0.6 mEq/L, p < 0.001) in anephric dogs without including any significant change in the levels of sodium, calcium, magnesium, albumin, total protein, or cholesterol. The platelet losses and changes in the plasma free hemoglobin levels observed were similar to those found with activated charcoal hemoperfusion. These results suggest that this resin hemoperfusion may be useful in patients with acute hyperkalemia. |
| Databáze: | OpenAIRE |
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