Diclofenac causes anastomotic leakage in the proximal colon but not in the distal colon of the rat
| Autor: | Rozemarijn J. van der Vijver, Roger M. L. M. Lomme, Simon T.K. Yauw, Kees van Laarhoven, Harry van Goor, Thijs Hendriks |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Diclofenac Colon Ileum Anastomotic Leak Anastomosis Gastroenterology chemistry.chemical_compound Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] Internal medicine Mechanical strength medicine Animals Proximal colon Rats Wistar Nonsteroidal business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine Rats stomatognathic diseases medicine.anatomical_structure Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] chemistry Anastomotic leakage Surgery Distal colon business medicine.drug |
| Zdroj: | American Journal of Surgery, 210, 2, pp. 382-8 American Journal of Surgery, 210, 382-8 |
| ISSN: | 0002-9610 |
| Popis: | Item does not contain fulltext BACKGROUND: Nonsteroidal anti-inflammatory drugs have been associated with anastomotic leakage. It was studied if diclofenac affects anastomoses differently depending on the location in the gut. METHODS: Ninety-five rats were randomized to 6 groups with an anastomosis in either ileum (IL), proximal colon (PC), or distal colon (DC). Groups IL+ (n = 10), PC+ (n = 30), and DC+ (n = 10) received diclofenac (3 mg/kg/day) from day 0 until sacrifice on day 3. Group PC- (n = 15) did not receive diclofenac. Groups PC1+ and PC2+ (n = 15 each) were given diclofenac from day 1 to 4 and from day 2 to 5. RESULTS: Leak rates were 10/10 in group IL+, 22/30 in PC+, 1/10 in DC+, and 1/15 in PC-. Delayed administration of diclofenac by 1 or 2 days (6/15, P = .05) resulted in reduced leakage rates. Mechanical strength results corresponded with leak rates. CONCLUSIONS: Diclofenac causes leakage of anastomoses in rat IL and PC, but not in the DC. This suggests a role for the ileal and proximal colonic content in diclofenac-induced leakage. |
| Databáze: | OpenAIRE |
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