A Longitudinal Analysis of Cerebral Blood Flow in Perinatally HIV Infected Adolescents as Compared to Matched Healthy Controls
| Autor: | Anne Marleen Ter Haar, Jason G. van Genderen, Henk J M M Mutsaerts, Malon Van den Hof, Charlotte Blokhuis, Vera C. Keil, Dasja Pajkrt |
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| Přispěvatelé: | Pediatric surgery, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, General Paediatrics, Amsterdam institute for Infection and Immunity, AII - Infectious diseases, Amsterdam Reproduction & Development (AR&D), APH - Methodology, APH - Societal Participation & Health, APH - Aging & Later Life |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cart medicine.medical_specialty Adolescent cerebral blood flow Thalamus Caudate nucleus HIV Infections Microbiology Article Cohort Studies White matter Young Adult Cognition Virology Internal medicine Basal ganglia Humans Medicine Child cognitive function Diagnostic Tests Routine business.industry Putamen Brain HIV QR1-502 Infectious Diseases medicine.anatomical_structure Anti-Retroviral Agents nervous system Cerebral blood flow Cerebrovascular Circulation Cohort Cardiology Female business circulatory and respiratory physiology |
| Zdroj: | Viruses, Vol 13, Iss 2179, p 2179 (2021) Viruses Viruses, 13(11):2179. Multidisciplinary Digital Publishing Institute Volume 13 Issue 11 Viruses, 13(11):2179. Multidisciplinary Digital Publishing Institute (MDPI) van Genderen, J G, Van den Hof, M, Ter Haar, A M, Blokhuis, C, Keil, V C, Pajkrt, D & Mutsaerts, H J M M 2021, ' A Longitudinal Analysis of Cerebral Blood Flow in Perinatally HIV Infected Adolescents as Compared to Matched Healthy Controls ', Viruses, vol. 13, no. 11, 2179 . https://doi.org/10.3390/v13112179 |
| ISSN: | 1999-4915 |
| Popis: | Despite effective combination anti-retroviral therapy (cART), perinatally HIV infected (PHIV) adolescents still experience cognitive complications. We previously reported higher cerebral blood flow (CBF) in basal ganglia and white matter (WM) in PHIV children compared to matched controls. In healthy children CBF is associated with cognitive domains. To determine longitudinal changes in CBF and its impact on cognitive complications, we measured CBF—using arterial spin labeling—in 21 PHIV adolescents and 23 controls matched for age, sex and socio-economic status twice with a mean follow-up of 4.6 years. We explored associations between CBF changes and WM micro- and macrostructural markers and cognitive domains using linear mixed models. The median age at follow-up was comparable between PHIV adolescents 17.4y (IQR:15.3–20.7) and controls 16.2y (IQR:15.6–19.1). At baseline, PHIV had higher CBF in the caudate nucleus and putamen. CBF development was comparable in gray matter (GM), WM and subcortical regions in both groups. In our cohort, we found that over time an increase of GM CBF was associated with an increase of visual motor function (p = 0.043) and executive function (p = 0.045). Increase of CBF in the caudate nucleus, putamen and thalamus was associated with an increase processing speed (p = 0.033 0.036 0.003 respectively) and visual motor function (p = 0.023 0.045 0.003 respectively). CBF development is relatively normal in PHIV adolescents on cART. CBF decline is associated with cognitive impairment, irrespective of HIV status. |
| Databáze: | OpenAIRE |
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