Extrapolation of toxic indices among test objects
| Autor: | Alena Vlková, Miloň Tichý, Rút Uzlová, Zdeněk Roth, Iveta Hanzlíková, Jana Tumová, Marián Rucki |
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| Rok vydání: | 2010 |
| Předmět: |
fish
Pharmacology Quantitative structure–activity relationship biology Ciliated protozoan QSAR Health Toxicology and Mutagenesis extrapolation Extrapolation acute toxicity Minnow ciliate Toxicology biology.organism_classification Acute toxicity oligochaeta Tubifex tubifex biology.animal Fish Original Article hepatocytes Pimephales promelas Biological system QAAR |
| Zdroj: | Interdisciplinary Toxicology |
| ISSN: | 1337-9569 1337-6853 |
| DOI: | 10.2478/v10102-010-0054-7 |
| Popis: | Extrapolation of toxic indices among test objectsOligochaetaTubifex tubifex, fish fathead minnow (Pimephales promelas), hepatocytes isolated from rat liver and ciliated protozoan are absolutely different organisms and yet their acute toxicity indices correlate. Correlation equations for special effects were developed for a large heterogeneous series of compounds (QSAR, quantitative structure-activity relationships). Knowing those correlation equations and their statistic evaluation, one can extrapolate the toxic indices. The reason is that a common physicochemical property governs the biological effect, namely the partition coefficient between two unmissible phases, simulated generally by n-octanol and water. This may mean that the transport of chemicals towards a target is responsible for the magnitude of the effect, rather than reactivity, as one would assume suppose. |
| Databáze: | OpenAIRE |
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