The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease
| Autor: | Judes Poirier, Uwe Beffert, Chantal Arguin |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Candidate gene Locus (genetics) Biology chemistry.chemical_compound Exon Alzheimer Disease Internal medicine Genotype medicine Humans alpha-Macroglobulins Receptors Immunologic Chromosome 12 Aged Aged 80 and over Genetics Polymorphism Genetic General Neuroscience Exons Middle Aged Endocrinology Receptors LDL chemistry Low-density lipoprotein LDL receptor Female lipids (amino acids peptides and proteins) Low Density Lipoprotein Receptor-Related Protein-1 |
| Zdroj: | Neuroscience Letters. 259:29-32 |
| ISSN: | 0304-3940 |
| Popis: | The low density lipoprotein receptor-related protein (LRP) gene is a candidate gene for Alzheimer's disease (AD) due to its role as a receptor for apolipoprotein E (apoE), a major genetic risk factor for late-onset familial and sporadic AD. Recently, several studies have reported a correlation between a polymorphism (C766T) in exon 3 of LRP and AD. We examined this polymorphism in a Caucasian population of 225 neuropathologically confirmed cases with AD and 187 elderly cases without any AD neuropathological changes. We found that the exon 3 LRP C/C genotype was slightly but not significantly higher in the AD group when compared to the control group. A meta-analysis of previous studies revealed only a weak correlation of this polymorphism with AD (odds ratio 1.34, [95% CI 1.16–1.54], P |
| Databáze: | OpenAIRE |
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