Airway and esophageal eosinophils in children with severe uncontrolled asthma
Autor: | Rasik Shah, Jessica Erkman, Jeremiah Levine, Leopoldo N. Segal, Allen Vaynblat, Kristen Thomas, Robert Giusti, Libia Moy, Mikhail Kazachkov, Melanie Greifer |
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Rok vydání: | 2017 |
Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Esophageal Mucosa Adolescent Biopsy Cystic fibrosis Gastroenterology Bronchoalveolar Lavage Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Internal medicine Bronchoscopy Medicine Humans Endoscopy Digestive System Reflux esophagitis Eosinophilic esophagitis Child Esophagitis Peptic Primary ciliary dyskinesia Asthma Retrospective Studies Bronchoscopy with Bronchoalveolar Lavage medicine.diagnostic_test Laryngoscopy business.industry Esophagogastroduodenoscopy Eosinophilic Esophagitis respiratory system medicine.disease respiratory tract diseases Eosinophils 030228 respiratory system Child Preschool Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Female business Airway Bronchoalveolar Lavage Fluid |
Zdroj: | Pediatric pulmonology. 53(12) |
ISSN: | 1099-0496 |
Popis: | Aim Children with severe uncontrolled asthma (SUA) have a high burden of symptoms and increased frequency of asthma exacerbations. Reflux esophagitis and eosinophilic esophagitis are important co-morbid factors for SUA. Both are associated with the presence of eosinophils in esophageal mucosa. We hypothesized that esophageal eosinophils are frequently present and correlate with the presence of airway eosinophils in children with SUA. Method We performed a retrospective analysis of a prospective database of children who underwent "triple endoscopy" (sleep laryngoscopy, bronchoscopy with bronchoalveolar lavage [BAL] and endobronchial biopsy [EBB], and esophagogastroduodenoscopy with esophageal biopsy [EsB]) at our Aerodigestive Center for evaluation of SUA. Children with known cystic fibrosis, primary ciliary dyskinesia, and aspiration-related lung disease were excluded. Result Twenty-four children (21 males) ages 2-16 years were studied. Elevated BAL eosinophils were found in 10 (42%) patients, endobronchial eosinophils in 16 (67%); 7 (29%) had endobronchial eosinophils without elevated BAL eosinophils. Esophageal eosinophils were found in 11 (46%) patients. There was a correlation between the amount of eosinophils in BAL and EBB (R = 0.43, P = 0.05) airway eosinophils, defined as elevated BAL and/or EBB eosinophils, correlated with esophageal eosinophils (R = 0.41, P = 0.047). Conclusion We concluded that airway and esophageal eosinophils are frequently present in children with SUA. |
Databáze: | OpenAIRE |
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