Airway and esophageal eosinophils in children with severe uncontrolled asthma

Autor: Rasik Shah, Jessica Erkman, Jeremiah Levine, Leopoldo N. Segal, Allen Vaynblat, Kristen Thomas, Robert Giusti, Libia Moy, Mikhail Kazachkov, Melanie Greifer
Rok vydání: 2017
Předmět:
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Esophageal Mucosa
Adolescent
Biopsy
Cystic fibrosis
Gastroenterology
Bronchoalveolar Lavage
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Internal medicine
Bronchoscopy
Medicine
Humans
Endoscopy
Digestive System
Reflux esophagitis
Eosinophilic esophagitis
Child
Esophagitis
Peptic
Primary ciliary dyskinesia
Asthma
Retrospective Studies
Bronchoscopy with Bronchoalveolar Lavage
medicine.diagnostic_test
Laryngoscopy
business.industry
Esophagogastroduodenoscopy
Eosinophilic Esophagitis
respiratory system
medicine.disease
respiratory tract diseases
Eosinophils
030228 respiratory system
Child
Preschool
Pediatrics
Perinatology and Child Health
030211 gastroenterology & hepatology
Female
business
Airway
Bronchoalveolar Lavage Fluid
Zdroj: Pediatric pulmonology. 53(12)
ISSN: 1099-0496
Popis: Aim Children with severe uncontrolled asthma (SUA) have a high burden of symptoms and increased frequency of asthma exacerbations. Reflux esophagitis and eosinophilic esophagitis are important co-morbid factors for SUA. Both are associated with the presence of eosinophils in esophageal mucosa. We hypothesized that esophageal eosinophils are frequently present and correlate with the presence of airway eosinophils in children with SUA. Method We performed a retrospective analysis of a prospective database of children who underwent "triple endoscopy" (sleep laryngoscopy, bronchoscopy with bronchoalveolar lavage [BAL] and endobronchial biopsy [EBB], and esophagogastroduodenoscopy with esophageal biopsy [EsB]) at our Aerodigestive Center for evaluation of SUA. Children with known cystic fibrosis, primary ciliary dyskinesia, and aspiration-related lung disease were excluded. Result Twenty-four children (21 males) ages 2-16 years were studied. Elevated BAL eosinophils were found in 10 (42%) patients, endobronchial eosinophils in 16 (67%); 7 (29%) had endobronchial eosinophils without elevated BAL eosinophils. Esophageal eosinophils were found in 11 (46%) patients. There was a correlation between the amount of eosinophils in BAL and EBB (R = 0.43, P = 0.05) airway eosinophils, defined as elevated BAL and/or EBB eosinophils, correlated with esophageal eosinophils (R = 0.41, P = 0.047). Conclusion We concluded that airway and esophageal eosinophils are frequently present in children with SUA.
Databáze: OpenAIRE
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