Synergistic effect between prelimbic 5-HT3 and CB1 receptors on memory consolidation deficit in adult male Sprague-Dawley rats: An isobologram analysis

Autor: Mohammad-Reza Zarrindast, M. Emam Ghoreishi, Mohammad Nasehi, Nargol Ahmadi-Mahmoodabadi
Rok vydání: 2015
Předmět:
0301 basic medicine
Agonist
Male
medicine.drug_class
medicine.medical_treatment
Biguanides
Arachidonic Acids
Pharmacology
Motor Activity
Serotonergic
Rats
Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Receptor
Cannabinoid
CB1
Oxazines
medicine
Avoidance Learning
Reaction Time
Serotonin receptor antagonist
Animals
Arachidonylcyclopropylamide
Serotonin receptor agonist
Cannabinoid Receptor Agonists
Cerebral Cortex
Memory Disorders
Dose-Response Relationship
Drug
Chemistry
General Neuroscience
Drug Synergism
Bridged Bicyclo Compounds
Heterocyclic
Rats
Serotonin Receptor Agonists
Disease Models
Animal
030104 developmental biology
Memory consolidation
Serotonin
Cannabinoid
Serotonin Antagonists
Receptors
Serotonin
5-HT3
Neuroscience
030217 neurology & neurosurgery
medicine.drug
Zdroj: Neuroscience. 317
ISSN: 1873-7544
Popis: The serotonergic system has often been defined as a neuromodulator system, and is specifically involved in learning and memory via its various receptors. Serotonin is involved in many of the same processes affected by cannabinoids. The present study investigated the influence of bilateral post-training intra-prelimbic (PL) administrations of serotonergic 5-hydroxytryptamine type-3 (5-HT3) receptor agents on arachidonylcyclopropylamide (ACPA) (cannabinoid CB1 receptor agonist)-induced amnesia, using the step-through inhibitory avoidance (IA) task to assess memory in adult male Sprague-Dawley rats. The results indicated that sole intra-PL microinjection of ACPA (0.1 and 0.5 μg/rat) and 5-HT3 serotonin receptor agonist (m-Chlorophenylbiguanide hydrochloride, m-CPBG; 0.001, 0.01 and 0.1 μg/rat) impaired, whereas Y-25130 (a selective 5-HT3 serotonin receptor antagonist; 0.001 and 0.01 and 0.1 μg/rat) did not alter IA memory consolidation, by itself. Moreover, intra-PL administration of subthreshold dose of m-CPBG (0.0005 μg/rat) potentiated, while Y-25130 (0. 1 μg/rat) restored ACPA-induced memory consolidation deficit. The isobologram analysis showed that there is a synergistic effect between ACPA and m-CPBG on memory consolidation deficit. These findings suggest that 5-HT3 receptor mechanism(s), at least partly, play(s) a role in modulating the effect of ACPA on memory consolidation in the PL area.
Databáze: OpenAIRE
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