The effect of omega‑3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID‑19: a randomized clinical trial

Autor: Seyed Alireza Mosavi Jarrahi, Mohammad Esmail Akbari, Narjes Ashouri Mirsadeghi, Fereshteh Ghorat, Seyedeh Elaheh Bagheri, Alireza Moslem, Maryam Gholamalizadeh, Samira Rastgoo, Mark O. Goodarzi, Parvin Joola, Mahdi Shadnoush, Saeid Doaei, Somayeh Gholami, Fatemeh Bourbour, Forough Samipoor, Azadeh Hajipour
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Blood Glucose
Male
0301 basic medicine
Respiratory System
lcsh:Medicine
Iran
Hematocrit
Kidney
Gastroenterology
law.invention
0302 clinical medicine
Randomized controlled trial
law
Medicine
Respiratory function
030212 general & internal medicine
Letter to the Editor
Blood urea nitrogen
Aged
80 and over
medicine.diagnostic_test
General Medicine
Middle Aged
Prognosis
Treatment Outcome
Female
Inflammation Mediators
Adult
medicine.medical_specialty
Mean arterial pressure
Diet therapy
Critical Illness
Renal function
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
Kidney function
Double-Blind Method
Internal medicine
Fatty Acids
Omega-3
Omega-3 fatty acids
Humans
Mortality
Aged
business.industry
SARS-CoV-2
Research
lcsh:R
COVID-19
Survival Analysis
Coronavirus
030104 developmental biology
Dietary Supplements
Base excess
Blood Gas Analysis
business
Biomarkers
Zdroj: Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-2 (2022)
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-9 (2021)
Journal of Translational Medicine
ISSN: 1479-5876
Popis: Background Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections. This paper aimed to examine the effect of n3-PUFA supplementation on inflammatory and biochemical markers in critically ill patients with COVID-19. Methods A double-blind, randomized clinical trial study was conducted on 128 critically ill patients infected with COVID-19 who were randomly assigned to the intervention (fortified formula with n3-PUFA) (n = 42) and control (n = 86) groups. Data on 1 month survival rate, blood glucose, sodium (Na), potassium (K), blood urea nitrogen (BUN), creatinine (Cr), albumin, hematocrit (HCT), calcium (Ca), phosphorus (P), mean arterial pressure (MAP), O2 saturation (O2sat), arterial pH, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), bicarbonate (HCO3), base excess (Be), white blood cells (WBCs), Glasgow Coma Scale (GCS), hemoglobin (Hb), platelet (Plt), and the partial thromboplastin time (PTT) were collected at baseline and after 14 days of the intervention. Results The intervention group had significantly higher 1-month survival rate and higher levels of arterial pH, HCO3, and Be and lower levels of BUN, Cr, and K compared with the control group after intervention (all P 2, PCO2, WBCs, GCS, Hb, Plt, PTT, and albumin between two groups. Conclusion Omega-3 supplementation improved the levels of several parameters of respiratory and renal function in critically ill patients with COVID-19. Further clinical studies are warranted. Trial registry Name of the registry: This study was registered in the Iranian Registry of Clinical Trials (IRCT); Trial registration number: IRCT20151226025699N3; Date of registration: 2020.5.20; URL of trial registry record: https://en.irct.ir/trial/48213
Databáze: OpenAIRE
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