Tumour-infiltrating lymphocytes (TILs)-related genomic signature predicts chemotherapy response in breast cancer
| Autor: | Shinobu Masuda, Mariko Kochi, Tadahiko Shien, Naoki Niikura, Giampaolo Bianchini, Naruto Taira, Junji Matsuoka, Toshiyoshi Fujiwara, Takayuki Motoki, Taeko Mizoo, Hiroyoshi Doihara, Tomohiro Nogami, Yutaka Tokuda, Takayuki Iwamoto |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Stromal cell Anthracycline Receptor ErbB-2 medicine.medical_treatment Breast Neoplasms chemical and pharmacologic phenomena Disease 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Breast cancer Internal medicine medicine Humans Breast Aged Chemotherapy business.industry hemic and immune systems Genomic signature Genomics Middle Aged Trastuzumab Gene signature Prognosis medicine.disease Neoadjuvant Therapy Gene Expression Regulation Neoplastic Gene expression profiling 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female business |
| Zdroj: | Breast Cancer Research and Treatment. 167:39-47 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-017-4502-3 |
| Popis: | The present study evaluated whether morphological-measured stromal and intra-tumour tumour-infiltrating lymphocytes (TILs) levels were associated with gene expression profiles, and whether TILs-associated genomic signature (GS) could be used to predict clinical outcomes and response to therapies in several breast cancer subtypes. We retrospectively evaluated haematoxylin eosin (HE)-TILs levels and gene expression profiling data from 40 patients with primary breast cancer and extracted the 22 overexpressed genes in cases with high TILs scores as the TILs-GS. The TILs-GS were compared with breast cancer subtype and were evaluated predictive values for prognosis and response to therapies. Higher TILs-GS expressions were observed for triple-negative and human epidermal growth factor receptor 2 (HER2) positive (+) breast cancers, compared to the luminal types (P |
| Databáze: | OpenAIRE |
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