Lateral orbitofrontal cortex anticipates choices and integrates prior with current information
| Autor: | Juan M. Abolafia, Emili Balaguer-Ballester, Jan Drugowitsch, Maria V. Sanchez-Vives, Ramon Nogueira, Rubén Moreno-Bote |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
media_common.quotation_subject Science Decision General Physics and Astronomy Prefrontal Cortex Sensory system Stimulus (physiology) Motor Activity Choice Behavior General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 0302 clinical medicine Perception Task Performance and Analysis Animals Rats Wistar Neural decoding Prior information media_common Neurons Multidisciplinary Lateral Orbitofrontal Cortex Behavior Animal General Chemistry 030104 developmental biology Neural encoding Orbitofrontal cortex Sensory processing Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NATURE COMMUNICATIONS r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017) Nature Communications r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname Recercat. Dipósit de la Recerca de Catalunya |
| ISSN: | 2041-1723 |
| Popis: | Adaptive behavior requires integrating prior with current information to anticipate upcoming events. Brain structures related to this computation should bring relevant signals from the recent past into the present. Here we report that rats can integrate the most recent prior information with sensory information, thereby improving behavior on a perceptual decision-making task with outcome-dependent past trial history. We find that anticipatory signals in the orbitofrontal cortex about upcoming choice increase over time and are even present before stimulus onset. These neuronal signals also represent the stimulus and relevant second-order combinations of past state variables. The encoding of choice, stimulus and second-order past state variables resides, up to movement onset, in overlapping populations. The neuronal representation of choice before stimulus onset and its build-up once the stimulus is presented suggest that orbitofrontal cortex plays a role in transforming immediate prior and stimulus information into choices using a compact state-space representation. The orbitofrontal cortex encodes outcomes, expected rewards and values, but it is unclear how this region uses this information to inform action selection. Here, the authors show that lateral orbitofrontal cortex anticipates upcoming choices and combines recent prior information with current sensory information. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|