Pharmacology of the new reversible inhibitor of monoamine oxidase A, RS-8359
| Autor: | Kurt Püchler, Astrid Plenker, Nobuyoshi Iwata |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Monoamine Oxidase Inhibitors Reserpine medicine.drug_class Monoamine oxidase Mice Inbred Strains Pharmacology chemistry.chemical_compound Mice Dogs Receptors Biogenic Amine Internal medicine Nitriles medicine Anticholinergic Animals Pharmacology (medical) Biogenic Monoamines Rats Wistar Brain Chemistry biology Hemodynamics Central Nervous System Depressants Biological activity Stereoisomerism Tyramine Antidepressive Agents Rats Psychiatry and Mental health Endocrinology Pyrimidines Mechanism of action chemistry biology.protein Respiratory Mechanics Antidepressant Serotonin Monoamine oxidase A medicine.symptom Psychology |
| Zdroj: | International clinical psychopharmacology. 12 |
| ISSN: | 0268-1315 |
| Popis: | RS-8359 is a new reversible inhibitor of monoamine oxidase A (RIMA). With a selectivity ratio of about 2200 for the A:B enzyme types, it is one of the most specific of this class of compounds. As a result, it shows relatively little effect upon blood pressure when administered together with tyramine, thus effectively eliminating the 'cheese' effect which has contributed to the limited clinical use of the classical monoamine oxidase inhibitors (MAOIs). RS-8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect. These characteristics suggest a relatively benign adverse event profile, which may be particularly advantageous in the elderly and may generally contribute to patient acceptance and compliance. In terms of its effects upon serotonin (5-hydroxytryptamine), RS-8359 gives increases similar to those of other MAOIs with activity sustained for about 9 h. In behavioural investigations, the compound gives results similar to those found with several antidepressants widely used in the clinic. Overall, the pharmacology of RS-8359 indicates that it should have antidepressant activity in man. |
| Databáze: | OpenAIRE |
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