Levels of C-reactive protein and protein C in periodontitis patients with and without cardiovascular disease
| Autor: | Nesrin Emekli, Isik Basar, Ülkü Noyan, Sehkar Oktay, Ezgi Malali, Ebru Emekli-Alturfan, Faruk Ayan, Eser Elemek |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Pathology medicine.drug_class Gastroenterology Severity of Illness Index Tooth Loss Physiology (medical) Internal medicine Severity of illness medicine Tooth loss Humans Periodontitis Aged Aged 80 and over Inflammation biology business.industry C-reactive protein Anticoagulant Hematology Middle Aged medicine.disease Chronic periodontitis C-Reactive Protein Cardiovascular Diseases biology.protein Female medicine.symptom business Protein C Biomarkers medicine.drug |
| Zdroj: | Pathophysiology of haemostasis and thrombosis. 37(1) |
| ISSN: | 1424-8840 |
| Popis: | Since periodontitis is a chronic and inflammatory disease, a number of hypotheses have proposed that it has an etiological or modulating role in cardiovascular disease (CVD). This study aimed to ascertain the changes in the plasma levels of C-reactive protein (CRP) and protein C (PC), a natural anticoagulant also having an anti-inflammatory effect, in patients who have mild-to-severe periodontitis with or without CVD. The test group consisted of 26 patients with CVD and chronic periodontitis and the control group consisted of 26 patients with chronic periodontitis and no systemic disease. In both groups Community Periodontal Index of Treatment Needs scores were recorded and blood samples were collected. CRP levels were significantly high and PC activity was significantly low in the test group compared to the control group (p < 0.001). There was a negative correlation between tooth loss and PC and between CRP and PC. How PC is affected by the inflammatory events and its association with CRP is an active area of investigation. |
| Databáze: | OpenAIRE |
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