Subacute dementia and imaging correlates in a case of Fahr's disease
| Autor: | Josef Marksteiner, Thomas Benke, Elfriede Karner, E. Donnemiller, K. Seppi, M. Delazer |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Psychosis Pediatrics medicine.medical_specialty Anterograde amnesia Short Report Anxiety Irritability Basal Ganglia Diseases Fluorodeoxyglucose F18 Basal ganglia medicine Dementia Humans Apathy Social Behavior Dysexecutive syndrome Calcinosis Syndrome Middle Aged medicine.disease Aggression Psychiatry and Mental health Disinhibition Surgery Neurology (clinical) medicine.symptom Radiopharmaceuticals Psychology Cognition Disorders Neuroscience Tomography Emission-Computed |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry. 75(8) |
| ISSN: | 0022-3050 |
| Popis: | We report a case of idiopathic bilateral basal ganglia calcinosis, or Fahr’s disease (FD) in a 50 year old patient who developed rapidly progressive behavioural abnormalities and severe neuropsychological impairments, but no movement disorder. Neuropsychological deficits included a severe dysexecutive syndrome, anterograde amnesia, and attentional impairment. Neuropsychiatric features comprised apathy with intermittent disinhibition, anxiety, irritability, frequent mood changes, ritualistic and antisocial behaviour, and psychosis. Fluorodeoxyglucose positron emission tomography showed a massive reduction of glucose metabolism in the basal ganglia and the frontal brain. The observed abnormalities possibly result from a disruption of frontostriatal circuits, presumably at the basal ganglia level. This case indicates that FD may cause exclusively behavioural alterations and that the associated hypometabolism in certain frontal areas is closely related to the clinical picture. |
| Databáze: | OpenAIRE |
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