Route of Infection Affects Pathogenicity of Leishmania major in BALB/c Mice
| Autor: | Ali Najafi, Firoozeh Abrishami, Maryam Abolghazi, Ehsan Sarreshteh, Mosayeb Rostamian, Mahsa Tat Asadi, Hamid M. Niknam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Microbial pathogenesis
medicine.medical_specialty biology Animal health Host (biology) leishmania major viscera biology.organism_classification Pathogenicity administration routes BALB/c Microbiology Medical microbiology Vector (epidemiology) medicine lcsh:Pathology pathogenicity Leishmania major balb/c mice lcsh:RB1-214 |
| Zdroj: | Journal of Medical Microbiology and Infectious Diseases, Vol 5, Iss 1, Pp 26-30 (2017) |
| ISSN: | 2345-5330 2345-5349 |
| Popis: | Introduction: The term Leishmaniasis applies to a group of parasitic diseases caused by the genus Leishmania. Route of infection is one of the variables that have been reported to influence the immune responses as well as the disease outcome in experimental models of leishmaniasis. This research aims to study the effect of route of infection on the pathogenicity of Leishmania major in BALB/c mice. Methods: Low (103 parasites/mouse) and high (106 parasites/mouse) doses of L. major was injected into footpad or ear dermis of BALB/c mice. Lesion diameter was determined throughout the study. Parasite load of draining lymph nodes and spleen were assessed at three intervals. Results: Footpad in comparison to ear route showed higher pathogenicity of L. major in BALB/c mice as assessed by lesion diameter, parasite load in the draining lymph node, and dissemination of the parasite to the spleen. Conclusion: Our findings suggest that substantial differences between footpad and ear route need particular attention when we use experimental models for the study of Leishmania infections. |
| Databáze: | OpenAIRE |
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